Choromanska Anna, Kulbacka Julita, Saczko Jolanta, Surowiak Pawel
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Department of Histology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Biomed Rep. 2020 Oct;13(4):32. doi: 10.3892/br.2020.1339. Epub 2020 Jul 31.
Gliomas are a group of malignant brain tumors. Despite significant efforts to optimize treatment options for patients with high-grade glioma, the prognosis of the overwhelming majority of patients remain poor. This bleak prognosis despite treatment of the glioma, is partly due to the tendency of therapeutics to diffusely penetrate into the neighboring brain tissues, but also due to the innate resistance of these tumors to chemotherapy and radiation. Garlic contains water-soluble and oil-soluble sulfur compounds. The oil-soluble compounds, including diallyl sulfide, diallyl disulfide (DADS), diallyl trisulfide and ajoene, are more effective potential anti-cancer treatments than the water-soluble compounds. There are several studies examining the effects of oil-soluble compounds on various types of cancer cells, although, to the best of our knowledge, there are no studies examining the effects of these compounds on glioma cells. The aim of the present study was to investigate the potential anti-glioma properties of DAD and garlic oil on proliferation and induction of apoptosis in four different types of glioma cell lines representative of different grades of the disease. The results showed that garlic oil exhibits favorable anti-cancer potential towards gliomas of various degrees of differentiation.
神经胶质瘤是一类恶性脑肿瘤。尽管人们为优化高级别神经胶质瘤患者的治疗方案付出了巨大努力，但绝大多数患者的预后仍然很差。尽管对神经胶质瘤进行了治疗，但预后不佳，部分原因是治疗药物倾向于扩散到邻近脑组织中，也归因于这些肿瘤对化疗和放疗的固有抗性。大蒜含有水溶性和油溶性硫化合物。油溶性化合物，包括二烯丙基硫醚、二烯丙基二硫醚（DADS）、二烯丙基三硫醚和阿霍烯，比水溶性化合物更具潜在的有效抗癌治疗作用。有多项研究探讨了油溶性化合物对各种癌细胞的影响，不过据我们所知，尚无研究探讨这些化合物对神经胶质瘤细胞的影响。本研究的目的是研究DAD和大蒜油对代表不同疾病分级的四种不同类型神经胶质瘤细胞系增殖和诱导凋亡的潜在抗神经胶质瘤特性。结果表明，大蒜油对不同分化程度的神经胶质瘤具有良好的抗癌潜力。
