Song Xiuxiu, Yue Ziqi, Nie Lulingxiao, Zhao Pengfei, Zhu Kangjian, Wang Qi
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Evid Based Complement Alternat Med. 2021 Oct 29;2021:5103626. doi: 10.1155/2021/5103626. eCollection 2021.
Garlic is widely accepted as a functional food and an excellent source of pharmacologically active ingredients. Diallyl disulfide (DADS), a major bioactive component of garlic, has several beneficial biological functions, including anti-inflammatory, antioxidant, antimicrobial, cardiovascular protective, neuroprotective, and anticancer activities. This review systematically evaluated the biological functions of DADS and discussed the underlying molecular mechanisms of these functions. We hope that this review provides guidance and insight into the current literature and enables future research and the development of DADS for intervention and treatment of multiple diseases.
大蒜被广泛认为是一种功能性食品，也是药理活性成分的优质来源。二烯丙基二硫化物（DADS）是大蒜的一种主要生物活性成分，具有多种有益的生物学功能，包括抗炎、抗氧化、抗菌、心血管保护、神经保护和抗癌活性。本综述系统评价了DADS的生物学功能，并讨论了这些功能的潜在分子机制。我们希望本综述能为当前文献提供指导和见解，并推动未来对DADS的研究以及将其用于多种疾病的干预和治疗。
