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Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients.

作者信息

Zhou Li-Kun, Zhou Zhen, Jiang Xia-Ming, Zheng Yishan, Chen Xi, Fu Zheng, Xiao Gengfu, Zhang Chen-Yu, Zhang Lei-Ke, Yi Yongxiang

机构信息

Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy, State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute of Life Sciences (NAILS), NJU Institute of AI Biomedicine and Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210023 China.

Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060 China.

出版信息

Cell Discov. 2020 Aug 5;6(1):54. doi: 10.1038/s41421-020-00197-3. eCollection 2020.

DOI:10.1038/s41421-020-00197-3
PMID:32802404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7406496/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32cd/7406496/8953b3f4c8c3/41421_2020_197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32cd/7406496/8953b3f4c8c3/41421_2020_197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32cd/7406496/8953b3f4c8c3/41421_2020_197_Fig1_HTML.jpg

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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.瑞德西韦和氯喹在体外能有效抑制新出现的新型冠状病毒（2019 - 新冠病毒）。
Cell Res. 2020 Mar;30(3):269-271. doi: 10.1038/s41422-020-0282-0. Epub 2020 Feb 4.
2
A pneumonia outbreak associated with a new coronavirus of probable bat origin.一种新型冠状病毒引发的肺炎疫情，该病毒可能来源于蝙蝠。
Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3.
3
Honeysuckle-derived microRNA2911 directly inhibits varicella-zoster virus replication by targeting IE62 gene.
金银花中的植物MIR2911对新冠病毒变异株有效。
Virus Res. 2025 Jul;357:199583. doi: 10.1016/j.virusres.2025.199583. Epub 2025 May 13.
4
Advancements in Plant-Derived sRNAs Therapeutics: Classification, Delivery Strategies, and Therapeutic Applications.植物源小RNA疗法的进展：分类、递送策略及治疗应用
Int J Mol Sci. 2025 Apr 30;26(9):4277. doi: 10.3390/ijms26094277.
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Qingkailing injection induces pseudo-allergic reactions via the MRGPRX2 pathway.清开灵注射液通过MRGPRX2途径诱发类过敏反应。
Am J Transl Res. 2025 Mar 15;17(3):2178-2187. doi: 10.62347/MFBU4210. eCollection 2025.
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J Nanobiotechnology. 2025 Mar 21;23(1):232. doi: 10.1186/s12951-025-03306-0.
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J Neurovirol. 2019 Aug;25(4):457-463. doi: 10.1007/s13365-019-00741-2. Epub 2019 May 28.
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Honeysuckle-encoded microRNA2911 inhibits Enterovirus 71 replication via targeting VP1 gene.忍冬苷编码 microRNA2911 通过靶向 VP1 基因抑制肠道病毒 71 复制。
Antiviral Res. 2018 Apr;152:117-123. doi: 10.1016/j.antiviral.2018.02.015. Epub 2018 Feb 16.
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Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses.金银花编码的非典型微小RNA2911直接靶向甲型流感病毒。
Cell Res. 2015 Jan;25(1):39-49. doi: 10.1038/cr.2014.130. Epub 2014 Oct 7.
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