Brown G D, Choi Y, Pampeno C, Meruelo D
Department of Pathology, New York University Medical Center, New York.
Crit Rev Immunol. 1988;8(3):175-215.
Early studies of the resistance and susceptibility of mouse strains to radiation-induced leukemia virus have demonstrated the important role of altered histocompatibility (H-2) antigen expression in the effectiveness of the immune response of the host to virus-infected and transformed cells. Changes in H-2 gene expression have now been correlated with disease resistance in a variety of viral systems. The experiments discussed indicate that viruses may directly or indirectly affect H-2 antigen expression at various levels of gene expression. These investigations generate a framework for approaching a molecular understanding of viral-induced changes in H-2 gene expression.
对小鼠品系对辐射诱导白血病病毒的抗性和易感性的早期研究表明，组织相容性（H-2）抗原表达改变在宿主对病毒感染和转化细胞的免疫反应有效性中起重要作用。现在，H-2基因表达的变化已与多种病毒系统中的抗病性相关联。所讨论的实验表明，病毒可能在基因表达的各个水平上直接或间接影响H-2抗原表达。这些研究为从分子层面理解病毒诱导的H-2基因表达变化建立了一个框架。
