Gheisari Farshid, Emami Melika, Raeisi Shahraki Hadi, Samipour Saeid, Nematollahi Parastoo
Ionizing and Non-Ionizing Radiation Protection Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Epidemiology and Biostatistics, Faculty of Health, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cardiol Res Pract. 2020 Jul 29;2020:6527820. doi: 10.1155/2020/6527820. eCollection 2020.
Identification of risk factors and their importance in different genders is essential in order to prevent, diagnose, and manage coronary artery disease (CAD) properly. The present study aims to investigate the role of gender in the distribution of different risk factors in ischemic heart disease. This study is a cross-sectional study. More than one thousand ( = 1012) patients referring to the Nuclear Medicine Department in Namazi Hospital, Shiraz, Iran, from March 2017 to March 2018 were studied. The patients' demographic data and their clinical history were collected. The results of the myocardial perfusion scan were recorded and compared between groups. Statistical analysis was implemented by SPSS version 18.0, and values below 0.05 were considered statistically significant. Out of the 1012 patients participating in this study, 698 (69%) were female and 314 (31%) were male. Ischemic heart disease (IHD) was significantly higher in men compared to women (19.1% versus 14.2%). The higher levels of systolic and diastolic blood pressures, along with older age, were a significant risk factor in women ( < 0.05). Previous myocardial infarction (MI), diabetes mellitus (DM), hypertension (HTN), and hyperlipidemia (HLP) had a strong correlation with IHD in our female population. Regarding the male subjects, previous MI and HLP had a lower correlation with IHD. Based on our logistic regression models, investigation of the simultaneous effects of risk factors on IHD showed that previous MI is the most effective risk factor in females (OR = 3.93) mostly in terms of residual ischemia in the infarcted myocardium. In the male population, on the other hand, HTN was identified as the most effective risk factor for IHD (OR = 2). In conclusion, we found that older age, higher blood pressure, DM, previous MI, HTN, and HLP have a significant association with IHD in the female population, whereas older age, DM, and HTN were significant risk factors for IHD in males. Also, the most effective factor for women was previous MI, while it was HTN for the male population.
为了正确预防、诊断和管理冠状动脉疾病（CAD），识别危险因素及其在不同性别中的重要性至关重要。本研究旨在调查性别在缺血性心脏病不同危险因素分布中的作用。本研究为横断面研究。对2017年3月至2018年3月期间前往伊朗设拉子纳马齐医院核医学科就诊的一千多名（n = 1012）患者进行了研究。收集了患者的人口统计学数据及其临床病史。记录心肌灌注扫描结果并在组间进行比较。采用SPSS 18.0版进行统计分析，P值低于0.05被认为具有统计学意义。在参与本研究的1012名患者中，698名（69%）为女性，314名（31%）为男性。男性的缺血性心脏病（IHD）显著高于女性（19.1%对14.2%）。收缩压和舒张压水平较高以及年龄较大是女性的重要危险因素（P < 0.05）。既往心肌梗死（MI）、糖尿病（DM）、高血压（HTN）和高脂血症（HLP）与我们女性人群中的IHD密切相关。对于男性受试者，既往MI和HLP与IHD的相关性较低。基于我们的逻辑回归模型，对危险因素对IHD的同时影响进行调查显示，既往MI是女性中最有效的危险因素（OR = 3.93），主要是就梗死心肌中的残余缺血而言。另一方面，在男性人群中，HTN被确定为IHD最有效的危险因素（OR = 2）。总之，我们发现年龄较大、血压较高、DM、既往MI、HTN和HLP与女性人群中的IHD显著相关，而年龄较大、DM和HTN是男性IHD的重要危险因素。此外，对女性最有效的因素是既往MI，而对男性人群则是HTN。
