Salam Latif A, Amin Khabbab, Cheng Regina, Murakami Noriyuki, Brown Clinton, Kwon Lawrence
Department of Internal Medicine, Section of Hospital Medicine, State University of New York (SUNY) Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Brooklyn Health Disparities Center, Division of Nephrology, State University of New York (SUNY) Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Case Rep Nephrol. 2020 Jul 31;2020:2932415. doi: 10.1155/2020/2932415. eCollection 2020.
Acute kidney injury (AKI) with progression to oliguric or anuric acute renal failure (ARF) is often related to use of well-known nephrotoxic agents including medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), angiotensin-converting enzyme inhibitors (ACEis)/angiotensin II receptor blockers (ARBs), and certain classes of antibiotics. Hyperosmolar IV contrast is also a well-known nephrotoxic agent. Severe sepsis with subsequent hypotension, marked hyperglycemia, and those with difficulty accessing water or with poor oral intake can also present with acute kidney injury related to kidney hypoperfusion, dehydration, and volume depletion. In this case report, we discover and discuss the possible effects of regular and daily occupational exposure of jet fuel (a mixture of hydrocarbons) on renal function. Jet fuel is an underdescribed and not well-known nephrotoxic agent; however, its direct toxicity on kidney function appears to be reversible with removal of exposure and aggressive fluid hydration.
急性肾损伤（AKI）进展为少尿或无尿性急性肾衰竭（ARF）通常与使用知名的肾毒性药物有关，包括非甾体类抗炎药（NSAIDs）、血管紧张素转换酶抑制剂（ACEIs）/血管紧张素II受体阻滞剂（ARBs）等药物以及某些类别的抗生素。高渗静脉造影剂也是一种知名的肾毒性药物。严重脓毒症继发低血压、明显高血糖以及那些难以获取水分或口服摄入量少的患者，也可能因肾脏灌注不足、脱水和容量耗竭而出现急性肾损伤。在本病例报告中，我们发现并讨论了日常职业性接触喷气燃料（碳氢化合物混合物）对肾功能可能产生的影响。喷气燃料是一种描述不足且不太知名的肾毒性药物；然而，随着接触的消除和积极的液体水化治疗，其对肾功能的直接毒性似乎是可逆的。
