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Radiat Res. 2019 Aug;192(2):159-168. doi: 10.1667/RR15346.1. Epub 2019 Jun 12.
2
Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death.立体定向体部放射治疗（SBRT）和立体定向放射手术（SRS）的生物学原理：间接细胞死亡。
Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):21-34. doi: 10.1016/j.ijrobp.2019.02.047. Epub 2019 Mar 2.
3
The Biology of SBRT: LQ or Something New?立体定向体部放疗的生物学原理：线性二次模型还是新的理论？
Int J Radiat Oncol Biol Phys. 2018 Jul 15;101(4):964. doi: 10.1016/j.ijrobp.2018.02.038. Epub 2018 Mar 6.
4
Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy.超声微泡增强放射治疗后肿瘤血管关闭和细胞死亡。
Theranostics. 2018 Jan 1;8(2):314-327. doi: 10.7150/thno.19010. eCollection 2018.
5
A hypothesis: indirect cell death in the radiosurgery era.一种假说：放射外科治疗时代的间接细胞死亡
Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):11-3. doi: 10.1016/j.ijrobp.2014.08.355.
6
Is indirect cell death involved in response of tumors to stereotactic radiosurgery and stereotactic body radiation therapy?间接细胞死亡是否参与肿瘤对立体定向放射外科和立体定向体部放射治疗的反应？
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The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?SRS 和 SBRT 的肿瘤放射生物学：涉及的不仅仅是 5 Rs 吗？
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Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer.剂量递增而非“新生物学机制”能够解释立体定向体部放射治疗对非小细胞肺癌的疗效。
Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):1159-60. doi: 10.1016/j.ijrobp.2012.11.003.
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A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy.适形调强放疗、立体定向体部放疗和高剂量率近距离放疗的广义线性能量传递-二次模型。
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立体定向体部放疗和立体定向放射治疗中的间接细胞死亡与线性二次模型

Indirect cell death and the LQ model in SBRT and SRS.

作者信息

Song Chang W, Terezakis Stephanie, Emami Bahman, Griffin Robert J, Sperduto Paul W, Kim Mi-Sook, Cho L Chinsoo

机构信息

Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.

Department of Radiation Oncology, Loyola University Medical Center Chicago, IL, USA.

出版信息

J Radiosurg SBRT. 2020;7(1):1-4.

PMID:32802572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7406346/
Abstract

High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.

摘要

高剂量低分割立体定向体部放疗（SBRT）和立体定向放射外科治疗（SRS）通过引起血管损伤间接杀死大量肿瘤细胞。当血管损伤继发的间接/额外肿瘤细胞死亡较小时，线性二次（LQ）公式可能适用于SBRT和SRS的某些临床病例。然而，当间接细胞死亡广泛时，LQ模型将低估SBRT和SRS的临床疗效。