立体定向体部放疗和立体定向放射治疗中的间接细胞死亡与线性二次模型
Indirect cell death and the LQ model in SBRT and SRS.
作者信息
Song Chang W, Terezakis Stephanie, Emami Bahman, Griffin Robert J, Sperduto Paul W, Kim Mi-Sook, Cho L Chinsoo
机构信息
Department of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN, USA.
Department of Radiation Oncology, Loyola University Medical Center Chicago, IL, USA.
出版信息
J Radiosurg SBRT. 2020;7(1):1-4.
Abstract
High-dose hypofractionated SBRT and SRS indirectly kills substantial fractions of tumor cells via causing vascular damage. The LQ formula may work well for certain clinical cases of SBRT and SRS when the indirect/additional tumor cell death secondary to vascular damage is small. However, when the indirect cell death is extensive, the LQ model will underestimate the clinical outcome of SBRT and SRS.
摘要
高剂量低分割立体定向体部放疗（SBRT）和立体定向放射外科治疗（SRS）通过引起血管损伤间接杀死大量肿瘤细胞。当血管损伤继发的间接/额外肿瘤细胞死亡较小时，线性二次（LQ）公式可能适用于SBRT和SRS的某些临床病例。然而，当间接细胞死亡广泛时，LQ模型将低估SBRT和SRS的临床疗效。
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