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用于偏头痛的降钙素基因相关肽（CGRP）抑制剂

CGRP Inhibitors for Migraine.

作者信息

Mohanty Diksha, Lippmann Steven

机构信息

Dr. Mohanty is a Neurology Resident Physician, and Dr. Lippmann is a Psychiatry Emeritus Professor at the University of Louisville School of Medicine in Louisville, Kentucky.

出版信息

Innov Clin Neurosci. 2020 Apr 1;17(4-6):39-40.

PMID:32802591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7413335/
Abstract

Migraine headaches remain a significant medical concern; lots of people are adversely affected. Many existing pharmacotherapies have disappointing results. The pathophysiology is related to calcitonin gene-related peptide (CGRP) pathways. There is hope for better efficacy from the now-available CGRP inhibitor drugs made available to patients suffering these cephalgias.

摘要

偏头痛仍然是一个重大的医学问题；许多人受到了不利影响。许多现有的药物治疗效果令人失望。其病理生理学与降钙素基因相关肽（CGRP）通路有关。对于患有这些头痛的患者来说，现有的CGRP抑制剂药物有望带来更好的疗效。

相似文献

1
CGRP Inhibitors for Migraine.用于偏头痛的降钙素基因相关肽（CGRP）抑制剂
Innov Clin Neurosci. 2020 Apr 1;17(4-6):39-40.
2
History and Review of anti-Calcitonin Gene-Related Peptide (CGRP) Therapies: From Translational Research to Treatment.降钙素基因相关肽（CGRP）拮抗剂治疗的历史和综述：从转化研究到治疗。
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3
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本文引用的文献

1
Optimising migraine treatment: from drug-drug interactions to personalized medicine.优化偏头痛治疗：从药物相互作用到个体化医学。
J Headache Pain. 2019 May 17;20(1):56. doi: 10.1186/s10194-019-1010-3.
2
The need for new acutely acting antimigraine drugs: moving safely outside acute medication overuse.需要新型急性作用抗偏头痛药物：安全地走出急性药物过度使用。
J Headache Pain. 2019 May 16;20(1):54. doi: 10.1186/s10194-019-1007-y.
3
CGRP and the Trigeminal System in Migraine.降钙素基因相关肽与偏头痛的三叉神经系统。
Headache. 2019 May;59(5):659-681. doi: 10.1111/head.13529. Epub 2019 Apr 14.
4
CGRP Antagonists for the Treatment of Chronic Migraines: a Comprehensive Review.降钙素基因相关肽（CGRP）拮抗剂治疗慢性偏头痛：全面综述。
Curr Pain Headache Rep. 2019 Mar 14;23(5):29. doi: 10.1007/s11916-019-0768-y.
5
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.全球、区域和国家层面 195 个国家和地区 1990 年至 2017 年 354 种疾病和伤害导致的发病率、患病率和伤残损失寿命年：基于 2017 年全球疾病负担研究的系统分析。
Lancet. 2018 Nov 10;392(10159):1789-1858. doi: 10.1016/S0140-6736(18)32279-7. Epub 2018 Nov 8.
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CGRP Monoclonal Antibodies for the Preventative Treatment of Migraine.降钙素基因相关肽单克隆抗体用于偏头痛的预防性治疗。
Curr Pain Headache Rep. 2018 Apr 6;22(5):38. doi: 10.1007/s11916-018-0686-4.
7
The Biology of Monoclonal Antibodies: Focus on Calcitonin Gene-Related Peptide for Prophylactic Migraine Therapy.单克隆抗体的生物学：以降钙素基因相关肽为重点的预防性偏头痛治疗。
Neurotherapeutics. 2018 Apr;15(2):324-335. doi: 10.1007/s13311-018-0622-7.
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Direct and Indirect Healthcare Resource Utilization and Costs Among Migraine Patients in the United States.美国偏头痛患者的直接和间接医疗资源利用与成本。
Headache. 2018 May;58(5):700-714. doi: 10.1111/head.13275. Epub 2018 Feb 15.
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A Controlled Trial of Erenumab for Episodic Migraine.依瑞奈玛单抗治疗发作性偏头痛的对照试验。
N Engl J Med. 2017 Nov 30;377(22):2123-2132. doi: 10.1056/NEJMoa1705848.
10
CGRP - The Next Frontier for Migraine.降钙素基因相关肽——偏头痛治疗的新前沿
N Engl J Med. 2017 Nov 30;377(22):2190-2191. doi: 10.1056/NEJMe1712559.