Perea E J, Ayarra J, García Iglesias M C, García Luque I, Loscertales J
Department of Microbiology, University Hospital, Seville, Spain.
Chemotherapy. 1988;34(1):1-7. doi: 10.1159/000238539.
We have studied the penetration of cefuroxime and ceftazidime into lung tissue of 40 patients subjected to pulmonary surgery. Samples of blood and lung tissue were taken 1 and 2 h after antibiotic administration. Patients were randomly assigned to four dosage schedule groups: group A received a single intravenous injection of 750 mg cefuroxime; the lung tissue levels at 1 and 2 h were 9.6 +/- 3.1 and 4.54 +/- 2.64 micrograms/g of cefuroxime; the percentage penetration from serum into the lung tissue was 33.7 and 34.6%, respectively. Group B patients received three doses of 750 mg cefuroxime; lung tissue levels were 17.1 +/- 7.7 and 14.7 +/- 5.4 micrograms/g, the percentage of penetration being 89.1 and 102.8% at 1 and 2 h. Group C received a single intravenous injection of 1 g ceftazidime; the lung tissue levels were 16.3 +/- 10.1 and 10 +/- 5.04 micrograms/g; the percentage of penetration from serum was 38.3 and 35.3%. Group D received three doses of 1 g ceftazidime; the lung tissue concentrations were 11.98 +/- 7.5 and 8.5 +/- 7.3 micrograms/g and the percentage of penetration 35.1 and 32.2% at 1 and 2 h after last dose.
我们研究了头孢呋辛和头孢他啶在40例接受肺部手术患者肺组织中的渗透情况。在给予抗生素后1小时和2小时采集血液和肺组织样本。患者被随机分为四个剂量方案组：A组接受单次静脉注射750mg头孢呋辛；1小时和2小时时肺组织中的水平分别为9.6±3.1和4.54±2.64μg/g头孢呋辛；从血清渗透到肺组织中的百分比分别为33.7%和34.6%。B组患者接受三剂750mg头孢呋辛；肺组织水平为17.1±7.7和14.7±5.4μg/g，1小时和2小时时的渗透百分比分别为89.1%和102.8%。C组接受单次静脉注射1g头孢他啶；肺组织水平为16.3±10.1和10±5.04μg/g；血清渗透百分比为38.3%和35.3%。D组接受三剂1g头孢他啶；末次给药后1小时和2小时时肺组织浓度分别为11.98±7.5和8.5±7.3μg/g，渗透百分比为35.1%和32.2%。
