Hara T, Saeki H, Yamamoto A, Ohta K, Suzuki T, Ara M, Sugawara M, Sano Y, Sakuma H, Satoh K
Department of Plastic and Reconstructive Surgery, School of Medicine, Hirosaki University.
Jpn J Antibiot. 1988 Jan;41(1):10-7.
Concentrations of cefuroxime (CXM) in the skin and the serum of 24 patients were examined. CXM (0.75 g, 1.5 g) was administered to these patients intravenously in one shot. The skin and the serum were collected at 30 and 60 minutes after the injection. Concentrations of CXM in the skin were following: 0.75 g, 30 min.; 11.4 +/- 5.3 micrograms/g 60 min.; 9.5 +/- 4.7 micrograms/g 1.5 g, 30 min.; 17.1 +/- 6.8 micrograms/g 60 min.; 15.7 +/- 13.2 micrograms/g Concentration ratios (skin/serum) at 60 minutes after the injection were from 72.5% to 79.2%. The binding ratio of CXM to serum protein was 41%, which was lower than most other antibiotics. High concentration levels of CXM were maintained in the skin for a long time. Based on this study, we consider that CXM is effective in the skin surgery.
检测了24例患者皮肤和血清中头孢呋辛（CXM）的浓度。对这些患者一次性静脉注射CXM（0.75g、1.5g）。在注射后30分钟和60分钟采集皮肤和血清。皮肤中CXM的浓度如下：0.75g，30分钟时为11.4±5.3微克/克；60分钟时为9.5±4.7微克/克。1.5g，30分钟时为17.1±6.8微克/克；60分钟时为15.7±13.2微克/克。注射后60分钟时的浓度比（皮肤/血清）为72.5%至79.2%。CXM与血清蛋白的结合率为41%，低于大多数其他抗生素。CXM在皮肤中长时间维持高浓度水平。基于这项研究，我们认为CXM在皮肤手术中有效。
