Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangdong Guangzhou 510515, China.
Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangdong Guangzhou 510282, China.
J Immunol Res. 2020 Jul 31;2020:2340670. doi: 10.1155/2020/2340670. eCollection 2020.
Human body surfaces, such as the skin, intestines, and respiratory and urogenital tracts, are colonized by a large number of microorganisms, including bacteria, fungi, and viruses, with the gut being the most densely and extensively colonized organ. The microbiome plays an essential role in immune system development and tissue homeostasis. Gut microbiota dysbiosis not only modulates the immune responses of the gastrointestinal (GI) tract but also impacts the immunity of distal organs, such as the lung, further affecting lung health and respiratory diseases. Here, we review the recent evidence of the correlations and underlying mechanisms of the relationship between the gut microbiota and common respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), lung cancer, and respiratory infection, and probiotic development as a therapeutic intervention for these diseases.
人体表面，如皮肤、肠道、呼吸和泌尿生殖道，定植着大量的微生物，包括细菌、真菌和病毒，其中肠道是定植最密集和广泛的器官。微生物组在免疫系统发育和组织动态平衡中发挥着重要作用。肠道微生物失调不仅调节胃肠道（GI）道的免疫反应，还影响远端器官如肺部的免疫，进一步影响肺部健康和呼吸疾病。在这里，我们回顾了肠道微生物群与常见呼吸道疾病（包括哮喘、慢性阻塞性肺疾病（COPD）、囊性纤维化（CF）、肺癌和呼吸道感染）之间的相关性及其潜在机制的最新证据，并探讨了益生菌作为这些疾病治疗干预措施的发展。
