Vine Donna F, Beilin Lawrence J, Burrows Sally, Huang Rae-Chi, Hickey Martha, Hart Roger, Proctor Spencer D, Mori Trevor A
Metabolic and Cardiovascular Disease Laboratory, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.
Medical School, University of Western Australia, Royal Perth Hospital Unit, Perth, Australia.
J Endocr Soc. 2020 May 26;4(8):bvaa061. doi: 10.1210/jendso/bvaa061. eCollection 2020 Aug 1.
Adolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk.
The aim of this study was to determine the concentrations of fasting plasma apoB-lipoprotein remnants, apoB48 and apoB100, and their association with cardiometabolic risk factors and androgen indices in adolescent girls with and without PCOS.
Participants (n = 184) aged 17 years were recruited in the Menstruation in Teenagers Study from the Western Australian Pregnancy Cohort (Raine) Study.
Fasting plasma apo-B48 and -B100 lipoprotein remnant concentrations in adolescent girls with and without PCOS.
Fasting plasma apoB48-lipoprotein remnants but not apoB100-lipoprotein remnants were elevated in adolescent girls with increased cardiometabolic risk compared with those with lower cardiometabolic risk (13.91 ± 5.06 vs 12.09 ± 4.47 µg/mL, < .01). ApoB48-lipoprotein remnants were positively correlated with fasting plasma triglycerides (b = .43, < .0001). The prevalence of increased cardiometabolic risk factors was 2-fold higher in those diagnosed with PCOS (35.3%) than in those without PCOS (16.3%). Adolescents with PCOS have a 2-fold higher incidence of cardiometabolic risk factors than those without PCOS. Fasting apoB48-lipoprotein remnants are elevated in adolescent girls with a high prevalence of cardiometabolic risk factors.
患有多囊卵巢综合征（PCOS）的青少年发生包括血脂异常在内的心血管代谢危险因素的几率增加。致动脉粥样硬化载脂蛋白（apo）B-脂蛋白残粒与心血管疾病（CVD）风险增加相关。
本研究旨在确定有无PCOS的青春期女孩空腹血浆apoB-脂蛋白残粒、apoB48和apoB100的浓度，以及它们与心血管代谢危险因素和雄激素指标的关联。
设计、地点和参与者：从西澳大利亚妊娠队列（Raine）研究的青少年月经研究中招募了184名17岁的参与者。
有无PCOS的青春期女孩空腹血浆apo-B48和-B100脂蛋白残粒浓度。
与心血管代谢风险较低的青春期女孩相比，心血管代谢风险增加的青春期女孩空腹血浆apoB48-脂蛋白残粒升高，但apoB100-脂蛋白残粒未升高（13.91±5.06 vs 12.09±4.47µg/mL，P<.01）。ApoB48-脂蛋白残粒与空腹血浆甘油三酯呈正相关（b=.43，P<.0001）。被诊断为PCOS的患者（35.3%）心血管代谢危险因素增加的患病率是未患PCOS患者（16.3%）的2倍。患有PCOS的青少年发生心血管代谢危险因素的几率是未患PCOS青少年的2倍。心血管代谢危险因素患病率高的青春期女孩空腹apoB48-脂蛋白残粒升高。
