Division of Nutrition, Metabolic and Cardiovascular Diseases Laboratory, University of Alberta, Edmonton, Alberta, Canada.
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Pediatr Obes. 2021 May;16(5):e12745. doi: 10.1111/ijpo.12745. Epub 2020 Nov 4.
Cardiovascular disease (CVD) originates in childhood and risk is exacerbated in obesity. Mechanisms of the etiologic link between early adiposity and CVD-risk remain unclear. Postprandial or non-fasting dyslipidemia is characterized by elevated plasma triglycerides (TG) and intestinal-apolipoprotein(apo)B48-remnants following a high-fat meal and is a known CVD-risk factor in adults. The aim of this study was to determine (a) whether the fasting concentration of apoB48-remnants can predict impaired non-fasting apoB48-lipoprotein metabolism (fat intolerance) and (b) the relationship of these biomarkers with cardiometabolic risk factors in youth with or without obesity.
We assessed fasting and non-fasting lipids in youth without obesity (n = 22, 10 males, 12 females) and youth with obesity (n = 13, 5 males, 8 females) with a mean BMI Z-score of 0.19 ± 0.70 and 2.25 ± 0.31 (P = .04), respectively.
Fasting and non-fasting apoB48-remnants were elevated in youth with obesity compared to youth without obesity (apoB48: 18.04 ± 1.96 vs 8.09 ± 0.59, P < .0001, and apoB48 : 173.0 ± 20.86 vs 61.99 ± 3.44, P < .001). Furthermore, fasting plasma apoB48-remnants were positively correlated with the non-fasting response in apoB48 (r = 0.84, P < .0001) as well as other cardiometabolic risk factors including HOMA-IR (r = 0.61, P < .001) and leptin (r = 0.56, P < .0001).
Fasting apoB48-remnants are elevated in youth with obesity and predict apoB48 postprandial dyslipidemia. ApoB48-remnants are associated with the extent of fat intolerance and appear to be potential biomarker of CVD-risk in youth.
心血管疾病（CVD）起源于儿童期，肥胖会使其风险加剧。早期肥胖与 CVD 风险之间的因果关系的机制仍不清楚。餐后或非禁食血脂异常的特征是，在高脂肪餐后，血浆甘油三酯（TG）和肠载脂蛋白（apo）B48 残基升高，这是成人 CVD 的已知危险因素。本研究旨在确定：（a）空腹时 apoB48 残基的浓度是否可以预测非禁食时 apoB48 脂蛋白代谢受损（脂肪不耐受）；（b）这些生物标志物与肥胖或不肥胖的青少年的心血管代谢危险因素之间的关系。
我们评估了无肥胖的青少年（n = 22，男性 10 名，女性 12 名）和肥胖的青少年（n = 13，男性 5 名，女性 8 名）的空腹和非空腹血脂，平均 BMI Z 评分分别为 0.19 ± 0.70 和 2.25 ± 0.31（P =.04）。
与无肥胖的青少年相比，肥胖的青少年空腹和非空腹时的 apoB48 残基升高（apoB48：18.04 ± 1.96 对 8.09 ± 0.59，P <.0001，和 apoB48：173.0 ± 20.86 对 61.99 ± 3.44，P <.001）。此外，空腹血浆 apoB48 残基与 apoB48 的非禁食反应呈正相关（r = 0.84，P <.0001），以及其他心血管代谢危险因素，包括 HOMA-IR（r = 0.61，P <.001）和瘦素（r = 0.56，P <.0001）。
肥胖青少年的空腹 apoB48 残基升高，可预测 apoB48 餐后血脂异常。apoB48 残基与脂肪不耐受的程度有关，似乎是青少年 CVD 风险的潜在生物标志物。
