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癌症的化学预防:硒

Chemoprevention of cancer: selenium.

作者信息

Hocman G

机构信息

Research Institute of Preventive Medicine, Bratislava, Czechoslovakia.

出版信息

Int J Biochem. 1988;20(2):123-32. doi: 10.1016/0020-711x(88)90475-2.

DOI:10.1016/0020-711x(88)90475-2
PMID:3280357
Abstract
  1. Selenium intake (in the form of selenite, selenate, selenomethionine, etc.) protects the organism against the action of some kinds of carcinogens. 2. People and animals having less Se in their blood are at a higher risk of acquiring cancer than those whose blood contains more of this element. 3. This chemopreventive action is probably due to antioxidant properties of Se, its involvements in the enzyme glutathione peroxidase as well as in the inhibition of enzymes converting carcinogens to their ultimate forms in the cell. 4. An intake of 150-300 micrograms of Se daily is considered to be adequate to protect the human organism without exhibiting the toxic properties of this element.
摘要
  1. 摄入硒(以亚硒酸盐、硒酸盐、硒代蛋氨酸等形式)可保护机体免受某些致癌物的侵害。2. 血液中硒含量较低的人和动物比血液中该元素含量较高的人患癌风险更高。3. 这种化学预防作用可能归因于硒的抗氧化特性、其在谷胱甘肽过氧化物酶中的作用以及对细胞中使致癌物转化为其最终形式的酶的抑制作用。4. 每天摄入150 - 300微克的硒被认为足以保护人体且不会表现出该元素的毒性。

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Chemoprevention of cancer: selenium.癌症的化学预防:硒
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2
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Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention.膳食蛋氨酸对硒代蛋氨酸和亚硒酸盐在癌症化学预防中生物效价的差异影响。
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引用本文的文献

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Human Lung Cancer Cell Line A-549 ATCC Is Differentially Affected by Supranutritional Organic and Inorganic Selenium.人肺癌细胞系A-549 ATCC受超营养水平有机硒和无机硒的影响存在差异。
Bioinorg Chem Appl. 2014;2014:923834. doi: 10.1155/2014/923834. Epub 2014 Nov 12.
2
Role of selenium and zinc in the pathogenesis of food allergy in infants and young children.硒和锌在婴幼儿食物过敏发病机制中的作用。
Arch Med Sci. 2012 Dec 20;8(6):1083-8. doi: 10.5114/aoms.2012.32420. Epub 2012 Dec 19.
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Effects of selenomethionine in irradiated human thyroid epithelial cells and tumorigenicity studies.
硒代蛋氨酸对放射性人甲状腺上皮细胞的影响及其致瘤性研究。
Nutr Cancer. 2011;63(7):1114-21. doi: 10.1080/01635581.2011.605981. Epub 2011 Sep 14.
4
Evaluation of selenium supply and status of inhabitants in three selected rural and urban regions of the Czech Republic.捷克共和国三个选定城乡地区居民硒供应与状况评估。
Biol Trace Elem Res. 1995 Jan-Mar;47(1-3):365-75. doi: 10.1007/BF02790139.
5
Selenium. Nutritional, toxicologic, and clinical aspects.硒:营养、毒理学及临床方面
West J Med. 1990 Aug;153(2):160-7.
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Chemoprevention of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rat by the combined actions of selenium, magnesium, ascorbic acid and retinyl acetate.硒、镁、抗坏血酸和醋酸视黄酯联合作用对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺癌的化学预防作用
Jpn J Cancer Res. 1990 Dec;81(12):1239-46. doi: 10.1111/j.1349-7006.1990.tb02685.x.