Bernocchi D, Castiglioni C L
Medical Department, Camillo Corvi SpA, Piacenza, Italy.
J Int Med Res. 1988 Jan-Feb;16(1):1-18. doi: 10.1177/030006058801600101.
During the last 10-15 years, therapy with theophylline for the treatment of obstructive lung disease has been rationalized because of increased investigation into drug pharmacokinetics and metabolism and the introduction of new techniques for measuring drug concentration in plasma. Orally administered sustained-release preparations of theophylline have recently been introduced as therapy following the development of new technology. Such preparations allow more effective use of theophylline through increased patient compliance and the maintenance of more stable plasma theophylline concentrations.
在过去10到15年中，由于对茶碱药物的药代动力学和代谢研究的增加以及血浆中药物浓度测量新技术的引入，茶碱用于治疗阻塞性肺病的疗法已趋于合理化。随着新技术的发展，口服缓释茶碱制剂最近已被用作治疗药物。这类制剂通过提高患者的依从性以及维持更稳定的血浆茶碱浓度，使茶碱能得到更有效的利用。
