Colorado State University Flint Animal Cancer Center, Fort Collins, Colorado, USA.
Ontario Veterinary College Mona Campbell Centre for Animal Cancer, University of Guelph, Guelph, Ontario, Canada.
Vet Comp Oncol. 2021 Mar;19(1):109-114. doi: 10.1111/vco.12645. Epub 2020 Aug 28.
Exocrine pancreatic carcinoma is uncommon in the dog and the veterinary literature surrounding the disease is minimal. Twenty-three cases of canine exocrine pancreatic carcinoma were reviewed in a retrospective manner to obtain information on clinical presentation, behaviour and survival associated with the disease. Presenting clinical signs were nonspecific and included anorexia, lethargy, vomiting and abdominal pain. The overall median survival time was only 1 day but was confounded by the large number of dogs that were euthanized shortly after diagnosis. Metastatic disease was detected in 78% of cases at the time of diagnosis, attesting to the aggressive nature of the disease. Neither lymph node metastasis, tumour size nor tumour location had an impact on overall survival. Only one patient was a previous diabetic who is contrary to reports of the disease in people and felines. This retrospective study reaffirms the need for early detection measures to optimize disease control. However, the benefits of therapy with surgery or radiation and adjuvant chemotherapy remain to be elucidated in dogs with exocrine pancreatic carcinoma.
犬的外分泌胰腺肿瘤并不常见，兽医文献对此病的记载也很少。我们回顾性分析了 23 例犬外分泌胰腺肿瘤病例，以获得与该疾病相关的临床表现、行为和生存信息。出现的临床症状是非特异性的，包括厌食、嗜睡、呕吐和腹痛。整体中位生存时间仅为 1 天，但由于大量犬在诊断后不久即被安乐死，这一数据受到了影响。在诊断时，78%的病例已发生转移，这表明该疾病具有侵袭性。淋巴结转移、肿瘤大小和肿瘤位置均与总生存时间无关。只有 1 例是既往糖尿病患者，这与该疾病在人和猫中的报道相反。本回顾性研究再次证实，需要采取早期检测措施来优化疾病控制。然而，手术或放疗和辅助化疗对犬外分泌胰腺肿瘤的疗效仍有待阐明。
