Matsuyama Hojo Veterinary Clinic, Hojo, Matsuyama, Ehime, 799-2431, Japan.
Ve. C. Jiyugaoka Animal Medical Center, 3-24-9, Yakumo, Meguro-ku, Tokyo, Japan.
BMC Vet Res. 2022 Nov 2;18(1):383. doi: 10.1186/s12917-022-03485-0.
Sclerosing encapsulating peritonitis (SEP) is a rare clinical syndrome characterised by fibrosis and thickening of the peritoneum with massive adhesions of the abdominal organs. In humans, abdominal tumours, such as pancreatic adenocarcinoma, can be underlying diseases of SEP. This report describes a case of SEP in a dog with pancreatic ductal adenocarcinoma.
An 11-year-old male neutered French Bulldog presented with chronic vomiting. Ultrasonography revealed a mass in the centre of the abdomen. A small amount of ascites, interpreted as modified transudate, was present in the abdominal cavity. Computed tomography (CT) revealed peritoneal effusion with a thickened peritonium. Laparoscopy revealed a large nodular lesion occupying the central portion of the abdomen, continuous with the falciform ligament. Histological examination of the biopsy specimens of the mass, abdominal wall, and gastric peritoneum revealed marked fibroplasia with mild lymphoplasmacytic infiltrates. Based on these results, a tentative diagnosis of early stage sclerosing encapsulating peritonitis (SEP) was made. Prednisolone and tamoxifen were administered with the expectation of ameliorating SEP, however, the dog died 61 days post diagnosis. At autopsy, the intestinal loop and mesentery were encased in the fibrous membrane, which is a typical finding in SEP. Histopathology and immunohistochemistry of the samples obtained at autopsy supported the diagnosis of pancreatic ductal adenocarcinoma with peritoneal dissemination and distant metastasis with desmoplasia. The unexpectedly hardened skin, where previously laparoscopic ports were inserted, histologically contained the same carcinoma cells with desmoplasia.
To the best of our knowledge, this is the first report of canine SEP with pancreatic ductal adenocarcinoma that also caused metastasis to port insertion sites as well as distant organs.
硬化性包裹性腹膜炎（SEP）是一种罕见的临床综合征，其特征为纤维化和腹膜增厚，伴有大量腹部器官粘连。在人类中，胰腺腺癌等腹部肿瘤可能是 SEP 的潜在疾病。本报告描述了一例患有胰腺导管腺癌的犬 SEP 病例。
一只 11 岁雄性去势法国斗牛犬出现慢性呕吐。超声检查显示腹部中央有一肿块。腹腔内有少量腹水，被认为是改良渗出液。计算机断层扫描（CT）显示腹膜积液伴腹膜增厚。腹腔镜检查显示一个占据腹部中央的大结节性病变，与镰状韧带连续。肿块、腹壁和胃腹膜活检标本的组织学检查显示明显的纤维增生伴轻度淋巴浆细胞浸润。基于这些结果，初步诊断为早期硬化性包裹性腹膜炎（SEP）。给予泼尼松龙和他莫昔芬以改善 SEP，但该犬在诊断后 61 天死亡。尸检时，肠袢和肠系膜被纤维膜包裹，这是 SEP 的典型表现。尸检标本的组织病理学和免疫组织化学检查支持胰腺导管腺癌伴腹膜播散和远处转移伴纤维母细胞增生的诊断。先前腹腔镜端口插入部位的皮肤出乎意料地变硬，组织学上含有同样的带有纤维母细胞增生的癌性细胞。
据我们所知，这是首例报道的犬 SEP 合并胰腺导管腺癌，且还导致了端口插入部位和远处器官的转移。
