Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Quebec, Canada.
Center for Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA.
J Clin Invest. 2020 Sep 1;130(9):4540-4542. doi: 10.1172/JCI140585.
Orexin/hypocretin neurons located in the lateral hypothalamus play a critical role in the maintenance of arousal and contribute to the regulation of multiple homeostatic and behavioral processes. In this issue of the JCI, Tan and Hang et al. report that feeding a high-fat diet to mice compromised the function of the orexin system, leading to impairments in reward-seeking and active coping mechanisms. The researchers observed changes at the cellular and circuit levels suggesting that reduced excitability of orexin neurons affects behavior through induction of a hypoarousal state.
位于下丘脑外侧的食欲素/下丘脑分泌素神经元在维持觉醒中起着关键作用，并有助于调节多种稳态和行为过程。在本期 JCI 中，Tan 和 Hang 等人报告说，高脂饮食喂养小鼠会损害食欲素系统的功能，导致其在寻求奖励和主动应对机制方面受损。研究人员观察到细胞和回路水平的变化，表明食欲素神经元兴奋性降低通过诱导低觉醒状态来影响行为。
