Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania of the Health System, 1 Silverstein, 3400 Spruce St, Philadelphia, PA, 19103, USA.
Division of Hematology/Oncology, Hospital of the University of Pennsylvania, University of Pennsylvania Health System, 3400 Spruce St, Philadelphia, PA, USA.
Abdom Radiol (NY). 2021 Feb;46(2):745-748. doi: 10.1007/s00261-020-02703-3. Epub 2020 Aug 17.
MicroRNAs expressed by germ cell tumors represent a novel approach to detection of metastatic disease during staging, surveillance, and recurrence post-therapy. It has particular promise in settings of equivocal imaging, such as clinical stage I GCT, tumor marker negative stage IIA, or after chemotherapy. These miRNAs have the potential to change typical serum marker evaluation and imaging surveillance schedules.
生殖细胞肿瘤表达的 microRNAs 代表了一种在分期、监测和治疗后复发期间检测转移性疾病的新方法。在影像学表现不明确的情况下，如临床 I 期 GCT、肿瘤标志物阴性 IIA 期或化疗后，这种方法具有特别的应用前景。这些 microRNAs 有可能改变典型的血清标志物评估和影像学监测方案。
