放射科医生应该了解关于生殖细胞肿瘤的 microRNA (miRNA) 血清生物标志物。
What radiologists should know about microRNA (miRNA) serum biomarkers for germ cell tumors.
机构信息
Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania of the Health System, 1 Silverstein, 3400 Spruce St, Philadelphia, PA, 19103, USA.
Division of Hematology/Oncology, Hospital of the University of Pennsylvania, University of Pennsylvania Health System, 3400 Spruce St, Philadelphia, PA, USA.
出版信息
Abdom Radiol (NY). 2021 Feb;46(2):745-748. doi: 10.1007/s00261-020-02703-3. Epub 2020 Aug 17.
MicroRNAs expressed by germ cell tumors represent a novel approach to detection of metastatic disease during staging, surveillance, and recurrence post-therapy. It has particular promise in settings of equivocal imaging, such as clinical stage I GCT, tumor marker negative stage IIA, or after chemotherapy. These miRNAs have the potential to change typical serum marker evaluation and imaging surveillance schedules.
生殖细胞肿瘤表达的 microRNAs 代表了一种在分期、监测和治疗后复发期间检测转移性疾病的新方法。在影像学表现不明确的情况下，如临床 I 期 GCT、肿瘤标志物阴性 IIA 期或化疗后，这种方法具有特别的应用前景。这些 microRNAs 有可能改变典型的血清标志物评估和影像学监测方案。
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