Gavras H, Gavras I
Department of Medicine, Boston City Hospital, Massachusetts.
Hypertension. 1988 Mar;11(3 Pt 2):II37-41. doi: 10.1161/01.hyp.11.3_pt_2.ii37.
The purpose of this brief review is to separate the characteristic properties and side effects attributable to the pharmacology of the whole class of angiotensin converting enzyme (ACE) inhibitors from those attributable to the chemical structure and kinetics of each particular ACE inhibitor. The former would be predictable and probably similar for all agents and, therefore, would be expected to recur with each agent, whereas the latter are likely to be characteristic of individual compounds and may be avoidable by changing to another compound with similar pharmacology but different molecular structure.
本简要综述的目的是,将整个血管紧张素转换酶(ACE)抑制剂类药物药理学所具有的特性和副作用,与每种特定ACE抑制剂的化学结构及动力学所导致的特性和副作用区分开来。前者具有可预测性,且可能对所有药物都相似,因此预计每种药物都会出现,而后者可能是个别化合物所特有的,通过换用另一种具有相似药理学但分子结构不同的化合物有可能避免。