[低剂量胺碘酮所致急性肺毒性：病例报告]

[Acute amiodarone pulmonary toxicity with low impregnation dose: case report].

作者信息

Cabrera-Rego Julio O, Luzurriaga Navas José D, Yanes Quintana Alberto A

机构信息

Unidad de Cuidados Coronarios Intensivos, Hospital Manuel Fajardo, La Habana, Cuba. Adress: Zapata y D, Vedado, Plaza de La Revolución, La Habana, Cuba, Código postal: 10400. Email:

Departamento de Imagenología, Hospital Manuel Fajardo, La Habana, Cuba. ORCID: 0000-0002-0080-2738.

出版信息

Medwave. 2020 Aug 14;20(7):e7996. doi: 10.5867/medwave.2020.07.7996.

DOI:10.5867/medwave.2020.07.7996

PMID:32804921

Abstract

Amiodarone, considered a potent antiarrhythmic, is known to cause pulmonary toxicity. Chronic interstitial pneumonitis is the most common presentation. However, acute pulmonary toxicity is rare and has a higher case fatality rate. We present a 61-year-old patient with persistent atrial fibrillation who, after a one-month treatment with oral amiodarone at a low dose impregnation of 400 mg/day, develops acute pulmonary toxicity, with radiographic and tomographic resolution after antiarrhythmic suspension and steroid treatment.

摘要

胺碘酮被认为是一种强效抗心律失常药物，已知会导致肺毒性。慢性间质性肺炎是最常见的表现。然而，急性肺毒性罕见且病死率较高。我们报告一例61岁持续性心房颤动患者，在以400毫克/天的低剂量口服胺碘酮治疗1个月后发生急性肺毒性，在停用抗心律失常药物并给予类固醇治疗后，影像学表现和断层扫描结果有所改善。