Iskandar Said B, Abi-Saleh Bernard, Keith Rob L, Byrd Ryland P, Roy Thomas M
Veterans Affairs Medical Center, Mountain Home, TN 37684, USA.
South Med J. 2006 Apr;99(4):383-7. doi: 10.1097/01.smj.0000208971.43461.bb.
Amiodarone is increasingly prescribed for patients with ventricular and supraventricular tachyarrhythmias. Many adverse effects have been reported due to this drug and include injury to the liver, thyroid, cornea, skin, and neuromuscular system. Pulmonary toxicity is one of the more serious side effects of this anti-arrhythmic drug and is potentially fatal. Since the first case of amiodarone-induced pneumonitis was described in the early 1980s, amiodarone pneumonitis has been recognized as a distinctive and not uncommon form of drug-induced lung injury. On the other hand, amiodarone-induced pulmonary toxicity resulting in alveolar hemorrhage is rare. The authors report a patient with amiodarone-induced alveolar hemorrhage and review the literature.
胺碘酮越来越多地被用于治疗室性和室上性快速心律失常患者。该药物已报告有许多不良反应，包括对肝脏、甲状腺、角膜、皮肤和神经肌肉系统的损害。肺毒性是这种抗心律失常药物较严重的副作用之一，且有潜在致命性。自20世纪80年代初首例胺碘酮诱发的肺炎被描述以来，胺碘酮肺炎已被公认为药物性肺损伤的一种独特且并不罕见的形式。另一方面，胺碘酮诱发的导致肺泡出血的肺毒性较为罕见。作者报告了一例胺碘酮诱发肺泡出血的患者并对文献进行了综述。
