胺碘酮所致肺毒性。

Amiodarone-induced pulmonary toxicity.

作者信息

Colby Rebecca, Geyer Holly

机构信息

Rebecca Colby practices at Northstate Cardiology Consultants in Chico, Calif. Holly Geyer practices hospital internal medicine at the Mayo Clinic in Phoenix, Ariz. The authors have disclosed no potential conflicts of interest, financial or otherwise.

出版信息

JAAPA. 2017 Nov;30(11):23-26. doi: 10.1097/01.JAA.0000524713.17719.c8.

DOI:10.1097/01.JAA.0000524713.17719.c8

PMID:29064934

Abstract

Amiodarone is widely used to prevent ventricular and supraventricular dysrhythmias but has a number of toxicities. One of the most devastating adverse reactions to this drug is pulmonary toxicity, which can present in a myriad of different ways. Toxicity is difficult to diagnose because many of its features also are seen in nontoxic patients. This article reviews the pathophysiology, presentation, diagnosis, and treatment of amiodarone-induced pulmonary toxicity.

摘要

胺碘酮被广泛用于预防室性和室上性心律失常，但有多种毒性。该药物最严重的不良反应之一是肺毒性，其表现形式多种多样。毒性难以诊断，因为其许多特征在无毒性的患者中也可见。本文综述了胺碘酮所致肺毒性的病理生理学、表现、诊断及治疗。