Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN.
Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN.
Ann Epidemiol. 2021 Jan;53:7-13.e2. doi: 10.1016/j.annepidem.2020.08.007. Epub 2020 Aug 15.
Personality traits have been reported to be associated with type 2 diabetes (T2DM) risk. The objective of this study was to examine whether and to what extent the associations between personality traits (dispositional optimism, hostility, and negative emotional expressiveness) and risk of T2DM were mediated by health behaviors and obesity.
Postmenopausal women (n = 110,992) aged 50-79 years without diabetes at enrollment in the Women's Health Initiative study (1993-1998) were followed up to 25 years. Incident diabetes was assessed via a validated self-report of physician-diagnosed diabetes treated with insulin or other hypoglycemic medications. Mediation analyses were performed using approaches under a counterfactual framework.
An inverse association of optimism with diabetes was significantly mediated by a factor primarily extracted from physical activity, diet quality, and sleep quality with a mediated proportion of 28%. Positive associations for hostility and negative emotional expressiveness were substantially mediated by a factor primarily composed of body mass index and waist circumference with mediated proportions of 32% and 44%, respectively.
Our data revealed that less than half of the associations between personality traits and risk of T2DM were explained by indirect health behavior pathways. Women's personality traits should be considered in prevention of diabetes in addition to promoting health behaviors.
已有研究报道人格特质与 2 型糖尿病（T2DM）风险相关。本研究旨在探讨人格特质（倾向性乐观、敌意和消极情绪表达）与 T2DM 风险之间的关联是否及在何种程度上受到健康行为和肥胖的中介作用。
参加妇女健康倡议研究（1993-1998 年）的无糖尿病的绝经后女性（n=110992）年龄为 50-79 岁，随访时间长达 25 年。通过经过验证的自我报告评估糖尿病的发病情况，即经医生诊断的糖尿病，采用胰岛素或其他降血糖药物治疗。使用反事实框架下的方法进行中介分析。
乐观与糖尿病之间呈负相关，该关联主要通过主要由体力活动、饮食质量和睡眠质量构成的因素来介导，中介比例为 28%。敌意和消极情绪表达的正相关主要通过主要由体重指数和腰围构成的因素来介导，中介比例分别为 32%和 44%。
我们的数据显示，人格特质与 T2DM 风险之间的关联中，仅有不到一半可通过间接的健康行为途径来解释。除了促进健康行为外，还应考虑女性的人格特质来预防糖尿病。
