Department of Pathology, Binzhou Medical University Hospital, Binzhou 256603, China.
Department of Surgery, Binzhou Medical University Hospital, Binzhou 256603, China.
Cardiovasc Pathol. 2020 Nov-Dec;49:107264. doi: 10.1016/j.carpath.2020.107264. Epub 2020 Jul 22.
We report a 60-year-old male with fibrin-associated diffuse large B-cell lymphoma (fa-DLBCL) in left atrial myxoma. Echocardiography showed a mass (63 mm × 33 mm) in the left atrium. Histological inspection indicated fa-DLBCL on the surface of atrial myxoma incidentally, together with extensive fibrinous like exudation on myxoma surface. Malignant cells were localized in solid sheets and nests at the peripheral area of the fibrinous exudation which were positive for B-lineage markers (CD20+, CD79a+, PAX-5+) and in situ hybridization of EBV-encoded RNA (EBER). PCR amplification showed clonal rearrangement of immunoglobulin heavy chain (IgH) genes. The patient was still alive with no recurrence in the 35-month follow-up after surgery. We also did a detailed clinicopathological analysis and literature review, which indicated that fa-DLBCL was a heterogeneous entity.
我们报告一例发生于左心房黏液瘤的纤维相关弥漫性大 B 细胞淋巴瘤（fa-DLBCL）。超声心动图显示左心房内有一肿物（63mm×33mm）。组织学检查发现，左心房黏液瘤表面偶然出现 fa-DLBCL，黏液瘤表面有广泛的纤维样渗出物。恶性细胞定位于纤维渗出物外周区的实性片层和巢状结构中，B 细胞标志物（CD20+、CD79a+、PAX-5+）阳性，原位杂交显示 EBV 编码的 RNA（EBER）阳性。PCR 扩增显示免疫球蛋白重链（IgH）基因呈克隆性重排。该患者术后 35 个月随访时仍存活，无复发。我们还进行了详细的临床病理分析和文献复习，表明 fa-DLBCL 是一种异质性实体。
