Yan J H, Luo D L, Zhang F, Chen Y, Luo X L, Xu J, Li Z, Liu Y H
Department of Pathology, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Zhonghua Bing Li Xue Za Zhi. 2020 Oct 8;49(10):1027-1030. doi: 10.3760/cma.j.cn112151-20200302-00160.
To investigate the clinicopathological features, treatment and prognosis of fibrin-associated diffuse large B cell lymphoma (DLBCL) arising within concurrent atrial myxoma. Six cases of fibrin-associated DLBCL arising within concurrent atrial myxoma diagnosed at the Department of Pathology, Guangdong General Hospital, from 2006 to 2019 were included. The histology, immunophenotype, treatment and prognoses were analyzed. The patients' age ranged from 46 to 78 years (mean 59 years). There were 3 males and 3 females. The tumors were all discovered incidentally on histological examination of surgical pathology specimens excised for atrial myxoma. All patients appeared to have morphological features of DLBCL, B lineage immunophenotype, high proliferative index and latency type III of Epstein-Barr viral infection. They had complete tumor resections without adjuvant chemotherapy and were healthy at 5- to 120-month follow-ups. Fibrin-associated DLBCL arising within concurrent atrial myxoma is an unusual form of DLBCL associated with chronic inflammation, and its clinical outcome is indolent. The findings suggest that this type of lymphoma does not warrant excessive or unnecessary treatments after complete resection.
探讨并发心房黏液瘤内纤维蛋白相关弥漫性大B细胞淋巴瘤（DLBCL）的临床病理特征、治疗及预后。纳入2006年至2019年在广东省人民医院病理科诊断的6例并发心房黏液瘤内纤维蛋白相关DLBCL病例。对其组织学、免疫表型、治疗及预后进行分析。患者年龄46至78岁（平均59岁）。男性3例，女性3例。所有肿瘤均在因心房黏液瘤切除的手术病理标本组织学检查时偶然发现。所有患者均表现出DLBCL的形态学特征、B细胞系免疫表型、高增殖指数及EB病毒感染的潜伏III型。他们均接受了肿瘤完整切除，未行辅助化疗，在5至120个月的随访中均健康。并发心房黏液瘤内纤维蛋白相关DLBCL是一种与慢性炎症相关的不寻常的DLBCL形式，其临床过程呈惰性。研究结果表明，这类淋巴瘤在完整切除后无需过度或不必要的治疗。
