College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China.
Advanced Research Institute and Department of Chemistry, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, P. R. China.
J Org Chem. 2020 Aug 21;85(16):10638-10647. doi: 10.1021/acs.joc.0c01207. Epub 2020 Aug 6.
An environmentally benign system for the direct alkylation of lawsones and 4-hydroxycoumarins with alcohols in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) is reported. The reaction proceeded smoothly via a dehydrative cross-coupling process by utilizing the unique properties of HFIP. A variety of alkylated products and subsequent one-pot cyclized products (pyranonaphthoquinones and pyranocoumarins) could be obtained in 40-93% yields.
报道了一种在 1,1,1,3,3,3-六氟异丙醇（HFIP）中用醇直接将劳森酮和 4-羟基香豆素烷基化的环境友好型体系。该反应通过利用 HFIP 的独特性质，通过脱水交叉偶联过程顺利进行。可以以 40-93%的收率得到各种烷基化产物和随后的一锅环化产物（吡喃并萘醌和吡喃香豆素）。
