College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
College of Chemical Engineering, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
J Org Chem. 2017 Feb 3;82(3):1610-1617. doi: 10.1021/acs.joc.6b02787. Epub 2017 Jan 17.
The metal-free cross-dehydrogenative coupling (CDC) reaction and subsequent cyclization of 2-hydroxy-1,4-naphthoquinone (lawsone) and 1,3-diarylpropene promoted by DDQ has been developed. 2-Hydroxy-3-alkyl-1,4-naphthoquinones and pyranonaphthoquinones with potential pharmaceutical applications are obtained in moderate to good yields. The reaction is also compatible for 4-hydroxycoumarins.
无金属的交叉脱氢偶联（CDC）反应和随后的 2-羟基-1,4-萘醌（lawsone）和 1,3-二芳基丙烯在 DDQ 促进下的环化反应已经被开发出来。得到了具有潜在药物应用的 2-羟基-3-烷基-1,4-萘醌和吡喃并萘醌，产率中等至良好。该反应也适用于 4-羟基香豆素。
