Qiu Xiaodong, Li Yangyang, Zhou Li, Chen Peishan, Li Fan, Zhang Yanan, Ling Yong
School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, China.
Org Lett. 2020 Aug 21;22(16):6424-6428. doi: 10.1021/acs.orglett.0c02236. Epub 2020 Jul 31.
A new protocol has been developed for the borylation of conjugated alkenyl methyl ethers using BPin via C-O bond cleavage catalyzed by Ni(II). In this cross-coupling reaction, both / isomers of alkenyl ethers are converted into ()-alkenyl boronic esters with good reactivity. This transformation exhibits high chemoselectivity in the presence of competitive C-O bonds such as aryl ether, ester, amide, and thioether groups, thus providing a new method for the construction of various alkenyl boronates.
已经开发出一种新的方案，用于通过镍（II）催化的C-O键裂解，使用联硼酸频哪醇酯对共轭烯基甲基醚进行硼化反应。在这种交叉偶联反应中，烯基醚的两种异构体均能以良好的反应活性转化为（）-烯基硼酸酯。在存在诸如芳基醚、酯、酰胺和硫醚基团等竞争性C-O键的情况下，这种转化表现出高化学选择性，从而为构建各种烯基硼酸酯提供了一种新方法。
