官能团相互转化：酯的脱羰基硼氢化反应用于合成有机硼酸酯
Functional Group Interconversion: Decarbonylative Borylation of Esters for the Synthesis of Organoboronates.
作者信息
Guo Lin, Rueping Magnus
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
King Abdullah University of Science and Technology (KAUST), KAUST Catalysis Center (KCC), Thuwal, 23955-6900, Saudi Arabia.
出版信息
Chemistry. 2016 Nov 14;22(47):16787-16790. doi: 10.1002/chem.201604504. Epub 2016 Oct 11.
A new and efficient nickel-catalyzed decarbonylative borylation reaction of carboxylic acid esters with bis(pinacolato)-diboron has been developed. This transformation allows access to structurally diverse aryl as well as alkenyl and alkyl boronate esters with high reactivity, broad substrate scope, and excellent functional-group tolerance. Further experiments show that this protocol can be carried out on a gram scale and applied to orthogonal synthetic strategies.
已开发出一种新型高效的镍催化羧酸酯与双(频哪醇合)二硼的脱羰硼化反应。这种转化能够以高反应活性、广泛的底物范围和出色的官能团耐受性获得结构多样的芳基以及烯基和烷基硼酸酯。进一步的实验表明，该方法可以在克级规模上进行，并应用于正交合成策略。
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