Roh Jiyeon, Shin Hyunjung, Hong Min-Ho
Research Planning and Coordination Division, National Forensic Service, Wonju-si 26460, Korea.
Nature Inspired Materials Processing Research Center, Department of Energy Science, Sungkyunkwan University, Suwon-si 16419, Korea.
Materials (Basel). 2020 Aug 12;13(16):3553. doi: 10.3390/ma13163553.
Dentin bonding is a key in restorative dentistry. Here, we developed a self-etching two-bottle adhesive system containing 10-methacryloyloxidecyl dihydrogen phosphate monomer (MDP) and the physical, mechanical, and biocompatible properties were evaluated. The characteristics of MDP were analyzed using nuclear magnetic resonance (NMR). Tests for water sorption and solubility, the shear-bond strengths to dentin and enamel, and cytotoxicity were performed. The newly-blended experimental group showed the lowest thickness and water sorption and solubility values. The shear bond strength of enamel and dentin were comparable to control groups (the three other products were Clearfil, UniFil, and AdheSE). All test groups showed 60% of cell viability. In this study, the properties of the newly-synthesized adhesive are comparable with the others. The fundamental goal of this study is to get the MDP patent released, as it is intended for domestic production. For this purpose, this dentin adhesive was developed and compared with the commercial product.
牙本质粘结是修复牙科的关键。在此，我们开发了一种含有10-甲基丙烯酰氧癸基二氢磷酸酯单体（MDP）的自酸蚀双瓶粘结系统，并对其物理、机械和生物相容性进行了评估。使用核磁共振（NMR）分析了MDP的特性。进行了吸水性和溶解性测试、与牙本质和釉质的剪切粘结强度测试以及细胞毒性测试。新混合的实验组显示出最低的厚度、吸水性和溶解性值。釉质和牙本质的剪切粘结强度与对照组（其他三种产品分别为Clearfil、UniFil和AdheSE）相当。所有测试组的细胞活力均为60%。在本研究中，新合成的粘结剂的性能与其他粘结剂相当。本研究的基本目标是使MDP专利获批，因为它打算用于国内生产。为此，开发了这种牙本质粘结剂并与商业产品进行了比较。
