干燥综合征：男性患者的临床谱
Sjögren's Syndrome: The Clinical Spectrum of Male Patients.
作者信息
Chatzis Loukas, Pezoulas Vasileios C, Ferro Francesco, Gandolfo Saviana, Donati Valentina, Binutti Marco, Callegher Sara Zandonella, Venetsanopoulou Aliki, Zampeli Evangelia, Mavrommati Maria, Argyropoulou Ourania D, Michalopoulos Giorgos, Voulgari Paraskevi V, Exarchos Themis, Baldini Chiara, Skopouli Fotini N, Fotiadis Dimitrios I, De Vita Salvatore, Moutsopoulos Haralampos M, Tzioufas Athanasios G, Goules Andreas V
机构信息
Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, 45110 Ioannina, Greece.
出版信息
J Clin Med. 2020 Aug 12;9(8):2620. doi: 10.3390/jcm9082620.
BACKGROUND
To compare the clinical, serological and histologic features between male and female patients with Sjögren's syndrome (SS) and explore the potential effect of gender on lymphoma development.
METHODS
From a multicenter population (Universities of Udine, Pisa and Athens, Harokopion and Ioannina (UPAHI)) consisting of consecutive SS patients fulfilling the 2016 ACR/EULAR criteria, male patients were identified, matched and compared with female controls. Data-driven multivariable logistic regression analysis was applied to identify independent lymphoma-associated factors.
RESULTS
From 1987 consecutive SS patients, 96 males and 192 matched female controls were identified and compared. Males had a higher frequency of lymphoma compared to females (18% vs. 5.2%, OR = 3.89, 95% CI: 1.66 to 8.67; = 0.0014) and an increased prevalence of serum anti-La/SSB antibodies (50% vs. 34%, OR = 1.953, 95% CI: 1.19 to 3.25; = 0.0128). No differences were observed in the frequencies of lymphoma predictors between the two genders. Data-driven multivariable logistic regression analysis revealed negative association of the female gender with lymphoma and positive association with lymphadenopathy.
CONCLUSION
Male SS patients carry an increased risk of lymphoma development. Although statistics showed no difference in classical lymphoma predictors compared to females, data-driven analysis revealed gender and lymphadenopathy as independent lymphoma-associated features.
背景
比较干燥综合征（SS）男性和女性患者的临床、血清学和组织学特征，并探讨性别对淋巴瘤发生的潜在影响。
方法
从一个多中心人群（乌迪内大学、比萨大学和雅典大学、哈罗科普利翁大学和约阿尼纳大学（UPAHI））中，选取符合2016年美国风湿病学会/欧洲抗风湿病联盟标准的连续SS患者，识别出男性患者，并与女性对照进行匹配和比较。应用数据驱动的多变量逻辑回归分析来确定独立的淋巴瘤相关因素。
结果
从1987例连续的SS患者中，识别并比较了96例男性和192例匹配的女性对照。男性淋巴瘤的发生率高于女性（18%对5.2%，OR = 3.89，95%CI：1.66至8.67；P = 0.0014），血清抗La/SSB抗体的患病率增加（50%对34%，OR = 1.953，95%CI：1.19至3.25；P = 0.0128）。在两种性别之间，淋巴瘤预测因素的频率未观察到差异。数据驱动的多变量逻辑回归分析显示女性性别与淋巴瘤呈负相关，与淋巴结病呈正相关。
结论
男性SS患者发生淋巴瘤的风险增加。尽管统计显示与女性相比，经典淋巴瘤预测因素没有差异，但数据驱动分析显示性别和淋巴结病是独立的淋巴瘤相关特征。
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