Mandosi Chiara, Matys Viviana, Deroma Marianna, Del Negro Valentina, Merlino Lucia, Mariani Marianna, Priori Roberta, Ciminello Enrico, Anastasi Emanuela, Porpora Maria Grazia, Piccioni Maria Grazia
Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
Rheumatology, Azienda Ospedaliera Universitaria Policlinico Umberto I, Sapienza University of Rome, Viale del, Policlinico 155, Rome, Italy.
Clin Rheumatol. 2025 Jan;44(1):319-325. doi: 10.1007/s10067-024-07241-7. Epub 2024 Nov 22.
This study aimed to assess the potential impact of primary Sjögren's syndrome (pSS) on fertility and ovarian reserve by evaluating the number of antral ovarian follicles (AFC) through ultrasound and analysing serum levels of anti-müllerian hormone (AMH) and follicle-stimulating hormone (FSH), which are currently the most reliable indicators of fertility potential.
A total of 52 premenopausal women were recruited from the Maternal, Infantile, and Urological Sciences Department at Umberto I Hospital, Sapienza University of Rome. Among them, 26 had pSS, and 26 served as healthy controls. All participants underwent a gynaecological examination, a transvaginal ultrasound, and serum testing for AMH and FSH levels.
The study found that serum AMH levels were significantly lower (p = 0.002) in pSS patients compared to the controls, indicating a potential reduction in ovarian reserve in these patients. However, no statistically significant differences were observed in FSH levels between the two groups.
The findings suggest that pSS may have a negative impact on ovarian reserve, as evidenced by lower AMH levels in comparison to age-matched controls. AFC and FSH levels, however, were similar to those of healthy women. These results provide new insights that could be beneficial for this patient population, though further, larger-scale studies are necessary to more comprehensively understand the relationship between pSS and female fertility. Key Points • The study assesses the possible impact of pSS on fertility and ovarian reserve by evaluation of AMH, FSH, and AFC. • Family planning and fertility are important issues for patients with rheumatic disorders and must be considered and discussed with the patient already at the time of diagnosis, and appropriate counselling must be performed.
本研究旨在通过超声评估窦状卵泡数量（AFC），并分析抗苗勒管激素（AMH）和促卵泡生成素（FSH）的血清水平，以评估原发性干燥综合征（pSS）对生育能力和卵巢储备的潜在影响，目前这两种激素是生育潜力最可靠的指标。
从罗马第一大学圣心医院母婴与泌尿科学系招募了52名绝经前女性。其中，26名患有pSS，26名作为健康对照。所有参与者均接受了妇科检查、经阴道超声检查以及AMH和FSH水平的血清检测。
研究发现，与对照组相比，pSS患者的血清AMH水平显著降低（p = 0.002），表明这些患者的卵巢储备可能降低。然而，两组之间的FSH水平未观察到统计学上的显著差异。
研究结果表明，与年龄匹配的对照组相比，pSS可能对卵巢储备有负面影响，AMH水平降低证明了这一点。然而，AFC和FSH水平与健康女性相似。这些结果提供了新的见解，可能对该患者群体有益，不过需要进一步的大规模研究来更全面地了解pSS与女性生育能力之间的关系。要点 • 本研究通过评估AMH、FSH和AFC来评估pSS对生育能力和卵巢储备的可能影响。 • 计划生育和生育对风湿病患者来说是重要问题，在诊断时就必须与患者进行考虑和讨论，并进行适当的咨询。
