Zakriski Audrey L, Wheeler Elizabeth, Burda Jeffrey, Shields Ann
Psychology Department, Connecticut College, 270 Mohegan Avenue, New London, CT 06320, USA. E-mail:
Bradley Hospital, Brown University School of Medicine, USA.
Child Adolesc Ment Health. 2005 Feb;10(1):16-22. doi: 10.1111/j.1475-3588.2005.00111.x.
This research investigated parent reports of pre-admission psychotropic medication histories of psychiatrically hospitalised children in the United States. The emphasis was on identifying factors related to potentially overzealous medication use.
Diagnosis, insurance type, and demographics for 170 consecutive admissions were assessed via research case conference and chart review. An extreme group of children with lengthy medication histories (n = 20) was also identified, and prescription and diagnostic patterns for this group were compared to other medicated children in the sample (n = 100). Cumulative medication history, rather than specific polypharmacy, was examined.
Psychopharmacotherapy was common (71%). Privately insured children, children with previous psychiatric hospitalisations, and children with Oppositional Defiant Disorder (ODD), Attention Deficit Hyperactivity Disorder (ADHD), and the specific comorbidities of ODD/ADHD, and ODD/Parent Child Relational Problems had more past medication trials. Depressed children had fewer. Analyses of the extreme group suggest that young, privately insured, oppositional children with parent-child relationship problems were at highest risk for overmedication (including multiple trials of stimulants, as well as mood stabilisers, central adrenergic agonists, and antipsychotics).
Results raise important questions about the role of health care pressures on clinical practice in the United States.
本研究调查了美国精神病住院儿童入院前精神药物治疗史的家长报告。重点是确定与潜在过度用药相关的因素。
通过研究病例讨论会和病历审查,对连续170例入院患者的诊断、保险类型和人口统计学特征进行评估。还确定了一组用药史较长的极端儿童(n = 20),并将该组的处方和诊断模式与样本中其他用药儿童(n = 100)进行比较。研究的是累积用药史,而非特定的联合用药情况。
心理药物治疗很常见(71%)。有私人保险的儿童、曾有过精神病住院史的儿童、患有对立违抗障碍(ODD)、注意力缺陷多动障碍(ADHD)以及ODD/ADHD和ODD/亲子关系问题特定共病的儿童,过去有更多的用药试验。抑郁儿童的用药试验较少。对极端组的分析表明,年轻、有私人保险、有亲子关系问题的对立儿童用药过量风险最高(包括多次使用兴奋剂、情绪稳定剂、中枢肾上腺素能激动剂和抗精神病药物)。
研究结果对美国医疗保健压力在临床实践中的作用提出了重要问题。