Van Leeuwen Willemijn, Nilsson Sofia, Merlo Juan
Unit for Social Epidemiology, Faculty of Medicine, Lund University, Malmö, Sweden.
BMJ Open. 2012 Sep 14;2(5). doi: 10.1136/bmjopen-2012-001260. Print 2012.
Besides medical needs, psychotropic medication use in adolescence might be conditioned by the cultural context of the family. This knowledge is relevant for both detecting inequities in healthcare, and identifying information bias in epidemiological studies using psychotropic medication as a proxy for impaired psychological health. Therefore, we investigated whether, independent of needs, the socioeconomic characteristics of the mother's country of birth are associated with psychotropic medication use in Swedish-born adolescents.
Prospective cohort study.
The Swedish population.
By linking the Swedish Medical Birth Registry to other national registers, we identified all 324 510 singletons born between 1988 and 1990 and who were alive and residing in Sweden until the age of 18 years (2006-2008).
The primary outcome was participants' use of psychotropic medication in the year they turned 18. In the analyses, applying a life-course approach, we included both the mother's and the children's characteristics throughout pregnancy, delivery, infancy, childhood and adolescence when calculating a risk score (RS) to adjust for needs. We classified the mother's country of birth according to the gross national income (GNI) per capita of each country.
Overall, the lower the income of the mother's birth country, the lower the probability of psychotropic medication use among children. When adjusting for needs, the association became even stronger.
Besides medical needs, use of psychotropic medication by descendants of immigrants seems conditioned by the socioeconomic characteristics of the mothers' countries of birth. The threat of information bias must be considered if psychotropic medication is used a proxy for impaired psychological health in descendants of immigrants.
除了医疗需求外,青少年使用精神药物可能还受家庭文化背景的影响。这一认识对于发现医疗保健中的不平等现象以及识别在以精神药物作为心理健康受损指标的流行病学研究中的信息偏差均具有重要意义。因此,我们调查了在不考虑需求的情况下,母亲出生国的社会经济特征是否与瑞典出生的青少年使用精神药物有关。
前瞻性队列研究。
瑞典人群。
通过将瑞典医疗出生登记处与其他国家登记处相链接,我们识别出了所有在1988年至1990年之间出生、直至18岁(2006 - 2008年)仍在世并居住在瑞典的324510名单胎婴儿。
主要结局是参与者在年满18岁当年使用精神药物的情况。在分析中,我们采用生命历程方法,在计算风险评分(RS)以调整需求时,纳入了整个孕期、分娩期、婴儿期、儿童期和青少年期母亲及儿童的特征。我们根据各国的人均国民总收入(GNI)对母亲的出生国进行分类。
总体而言,母亲出生国的收入越低,儿童使用精神药物的可能性就越低。在调整需求后,这种关联变得更强。
除医疗需求外,移民后代使用精神药物的情况似乎还受母亲出生国社会经济特征的影响。如果在移民后代中将精神药物用作心理健康受损的指标,则必须考虑信息偏差的威胁。