Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China.
Key Laboratory of Biomedical Photonics (HUST), Ministry of Education, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China.
ACS Appl Mater Interfaces. 2020 Sep 9;12(36):40052-40066. doi: 10.1021/acsami.0c10475. Epub 2020 Aug 28.
Ameliorated therapy based on the tumor microenvironment is becoming increasingly popular, yet only a few methods have achieved wide recognition. Herein, targeting multifunctional hydrophilic nanomicelles, AgBiS@DSPE-PEG-FA (ABS-FA), were obtained and employed for tumor treatment. In a cascade amplification mode, ABS-FA exhibited favorable properties of actively enhancing computed tomography/infrared (CT/IR) imaging and gently relieving ambient oxygen concentration by cooperative photothermal and sonodynamic therapy. Compared with traditional BiS nanoparticles, the CT imaging capability of the probe was augmented (43.21%), and the photothermal conversion efficiency was increased (33.1%). Furthermore, remarkable ultrasonic dynamic features of ABS-FA were observed, with increased generation of reactive oxygen species (24.3%) being obtained compared to Ce6, a commonly used sonosensitizer. Furthermore, ABS-FA exhibited obvious inhibitory effects on HeLa cell migration at 6 μg/mL, which to some extent, demonstrated its suppressive effect on tumor growth. A lower dose, laser and ultrasonic power, and shorter processing time endowed ABS-FA with excellent photothermal and sonodynamic effects. By mild cascade mode, the hypoxic condition of the tumor site was largely improved, and a suitable oxygen-rich environment was provided, thereby endowing ABS-FA with a superior synergistically enhanced treatment effect compared with the single-mode approach, which ultimately realized the purpose of "one injection, multiple treatment". Moreover, our data showed that ABS-FA was given with a biological safety profile while harnessing . Taken together, as a synergistically enhanced medical diagnosis and treatment method, the one-for-all nanoplatform will pave a new avenue for further clinical applications.
基于肿瘤微环境的改良疗法越来越受到关注，但仅有少数方法得到了广泛认可。在此，我们制备了一种多功能亲水性纳米胶束靶向药物，AgBiS@DSPE-PEG-FA（ABS-FA），并将其用于肿瘤治疗。在级联放大模式下，ABS-FA 表现出了良好的特性，能够通过光热和超声动力学协同治疗主动增强计算机断层扫描/红外（CT/IR）成像并温和缓解环境氧浓度。与传统的 BiS 纳米粒子相比，该探针的 CT 成像能力得到了增强（43.21%），光热转换效率提高了（33.1%）。此外，还观察到 ABS-FA 具有显著的超声动力学特性，与常用的声敏剂 Ce6 相比，活性氧的产生增加了（24.3%）。此外，ABS-FA 在 6 μg/mL 时对 HeLa 细胞迁移具有明显的抑制作用，在一定程度上表明其对肿瘤生长具有抑制作用。较低的剂量、激光和超声功率以及较短的处理时间赋予了 ABS-FA 优异的光热和超声动力学效应。通过温和的级联模式，肿瘤部位的缺氧状况得到了很大改善，并提供了一个适宜的富氧环境，从而使 ABS-FA 具有比单一模式更优越的协同增强治疗效果，最终实现了“一次注射，多种治疗”的目的。此外，我们的数据表明，在利用 ABS-FA 时，具有良好的生物安全性。综上所述，作为一种协同增强的医学诊断和治疗方法，这种多用途纳米平台将为进一步的临床应用开辟新的途径。
