Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, P. R. China.
Key Laboratory of Biomedical Photonics (HUST), Ministry of Education, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, P. R. China.
Nat Commun. 2022 Aug 5;13(1):4567. doi: 10.1038/s41467-022-32349-2.
Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co, which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. HS secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis.
低效的肿瘤治疗方法常常导致致命的肿瘤转移。在这里，我们报告了一种仿生多功能纳米平台，该平台明确设计为具有基于 Co 的金属有机骨架聚多巴胺杂化结构 (MOF-PDA)、茴香三硫酮 (ADT) 和巨噬细胞膜。肿瘤微环境中的 Co-MOF 降解会释放 Co，从而下调 HSP90 的表达并抑制细胞耐热性，从而提高 PDA 的光热治疗效果。ADT 酶解后 HS 的分泌导致高浓度气体治疗。此外，ADT 改变了肿瘤糖酵解过程中烟酰胺腺嘌呤二核苷酸/黄素腺嘌呤二核苷酸 (NADH/FAD) 的平衡。NADH 的消耗限制了 ATP 的合成，从而引发一定程度的肿瘤生长抑制并导致饥饿治疗。还在液氮中实现了 NADH/FAD 的增强的 2D/3D 自发荧光成像，并用于有效监测肿瘤治疗。所开发的仿生纳米平台为治疗原位肿瘤和抑制转移提供了一种方法。
