分期手术未能使希望保留生育能力的交界性卵巢肿瘤妇女受益：448 例回顾性分析。
Staging procedures fail to benefit women with borderline ovarian tumours who want to preserve fertility: a retrospective analysis of 448 cases.
机构信息
Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.
Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.
出版信息
BMC Cancer. 2020 Aug 17;20(1):769. doi: 10.1186/s12885-020-07262-w.
BACKGROUND
To evaluate the effect of clinicopathologic factors on the prognosis and fertility outcomes of BOT patients.
METHODS
We performed a retrospective analysis of BOT patients who underwent surgical procedures in West China Second University Hospital from 2008 to 2015. The DFS outcomes, potential prognostic factors and fertility outcomes were evaluated.
RESULTS
Four hundred forty-eight patients were included; 52 recurrences were observed. Ninety-two patients undergoing FSS achieved pregnancy. No significant differences in fertility outcomes were found between the staging and unstaged surgery groups. Staging surgery was not an independent prognostic factor for DFS. Laparoscopy resulted in better prognosis than laparotomy in patients with stage I tumours and a desire for fertility preservation.
CONCLUSION
Patients with BOT fail to benefit from surgical staging. Laparoscopy is recommended for patients with stage I disease who desire to preserve fertility. Physicians should pay more attention to risk of recurrence in patients who want to preserve fertility.
背景
评估临床病理因素对卵巢交界性肿瘤（BOT）患者预后和生育结局的影响。
方法
我们对 2008 年至 2015 年在华西第二医院接受手术治疗的 BOT 患者进行了回顾性分析。评估了无复发生存（DFS）结局、潜在的预后因素和生育结局。
结果
共纳入 448 例患者，观察到 52 例复发。92 例行保留生育功能手术（FSS）的患者妊娠。分期手术和未分期手术组的生育结局无显著差异。分期手术不是 DFS 的独立预后因素。对于有生育保留意愿的Ⅰ期肿瘤患者，腹腔镜手术较开腹手术具有更好的预后。
结论
BOT 患者无法从手术分期中获益。对于有生育保留意愿的Ⅰ期疾病患者，推荐使用腹腔镜手术。对于有生育保留意愿的患者，医生应更加关注复发的风险。
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