Nakayama Midori, Ono Masanori, Iizuka Takashi, Kagami Kyosuke, Fujiwara Tomoko, Sekizuka-Kagami Naomi, Maida Yoshiko, Obata Takeshi, Yamazaki Rena, Daikoku Takiko, Fujiwara Hiroshi
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
Department of Social Work and Life Design, Kyoto Notre Dame University, Kyoto, Japan.
J Obstet Gynaecol Res. 2020 Nov;46(11):2292-2297. doi: 10.1111/jog.14431. Epub 2020 Aug 18.
Hypertensive disorders of pregnancy (HDP) are serious conditions that occur in 5-10% of pregnancies. Maternal factors, such as maternal age, obesity, and renal disease, have been described as risk factors. In order to extract the background lifestyle and gynecological characteristics for HDP, we conducted a prospective cohort study.
Pregnant participants were administered a questionnaire on characteristics, menstrual abnormalities and lifestyle factors. The women were followed individually until 1-month postpartum. We used medical records to examine the relationship between menstrual abnormalities and the onset of HDP.
We collected data from 193 pregnant women, and excluding 3 who had miscarriage, examined the records of 190. A total of 26 patients developed HDP, of which 10 had early-onset HDP and 16 had late-onset HDP. Although there was no significant association between HDP and dysmenorrhea just prior to pregnancy, there was a significant increase in the incidence of HDP in patients who experienced dysmenorrhea around the age of 20 years (odds ratio 4.362 [95% CI 1.61-11.81]).
We found that patients with a history of dysmenorrhea around the age of 20 years have a significantly higher risk of developing HDP. Although dysmenorrhea in young adulthood is ameliorated, it may become apparent as a perinatal disease when a physical load such as pregnancy is applied.
妊娠高血压疾病（HDP）是5%-10%的妊娠中出现的严重病症。母体因素，如产妇年龄、肥胖和肾脏疾病，已被描述为风险因素。为了提取HDP的背景生活方式和妇科特征，我们进行了一项前瞻性队列研究。
对怀孕参与者进行了关于特征、月经异常和生活方式因素的问卷调查。对这些女性进行个体随访直至产后1个月。我们使用病历检查月经异常与HDP发病之间的关系。
我们收集了193名孕妇的数据，排除3名流产者后，检查了190人的记录。共有26名患者发生HDP，其中10名患有早发型HDP，16名患有晚发型HDP。虽然妊娠前痛经与HDP之间无显著关联，但20岁左右经历痛经的患者中HDP发病率显著增加（比值比4.362 [95%可信区间1.61-11.81]）。
我们发现20岁左右有痛经病史的患者发生HDP的风险显著更高。虽然年轻时的痛经会缓解，但当施加如怀孕这样的身体负担时，它可能会以围产期疾病的形式显现出来。
