National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610065, China.
Department of Orthopaedics, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
ACS Appl Mater Interfaces. 2020 Sep 16;12(37):40990-40999. doi: 10.1021/acsami.0c08291. Epub 2020 Aug 31.
Flexible bioelectronics for biomedical applications requires a stretchable, conductive, self-healable, and biocompatible material that can be obtained by cost-effective chemicals and strategies. Herein, we synthesized polypyrrole or Zn-functionalized chitosan molecules, which are cross-linked with poly(vinyl alcohol) to form a hydrogel through dynamic di-diol complexations, hydrogen bonding, and zinc-based coordination bonds. These multiple dynamic interactions endow the material with excellent stretchability and autonomous self-healing ability. The choice of Food and Drug Administration (FDA)-approved materials (poly(vinyl alcohol) and chitosan) as the matrix materials ensures the good biocompatibility of the hydrogel. The conductivity contributed by the polypyrrole allowed the hydrogel to sense strain and temperature, and the coordinated Zn significantly enhanced the antibacterial activity of the hydrogel. Moreover, using a diabetic rat model, we have proved that this hydrogel is capable of promoting the healing of the infected chronic wounds with electrical stimulation.
用于生物医学应用的柔性生物电子学需要一种具有可拉伸性、导电性、自修复性和生物相容性的材料，可以通过具有成本效益的化学物质和策略获得。在此，我们合成了聚吡咯或 Zn 功能化壳聚糖分子，它们通过动态二二醇络合、氢键和基于锌的配位键与聚乙烯醇交联形成水凝胶。这些多种动态相互作用赋予材料优异的拉伸性和自主自修复能力。选择获得美国食品和药物管理局 (FDA) 批准的材料（聚乙烯醇和壳聚糖）作为基质材料确保了水凝胶的良好生物相容性。聚吡咯提供的导电性使水凝胶能够感知应变和温度，而配位的 Zn 则显著增强了水凝胶的抗菌活性。此外，我们使用糖尿病大鼠模型证明，这种水凝胶能够在电刺激下促进感染性慢性伤口的愈合。
