[导电水凝胶及其在糖尿病伤口修复中的应用研究进展]
[Research advances on conductive hydrogels and their applications in the repair of diabetic wounds].
作者信息
Lyu Y, Chu W L, Chen Y, Li Y J, Ma X L
机构信息
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China.
Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.
出版信息
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jun 20;39(6):586-590. doi: 10.3760/cma.j.cn501225-20220929-00425.
As a new type of functional wound dressing, conductive hydrogel, shows broad prospects of application in the field of wound repair due to its suitable electrical conductivity, good moisture retention, excellent biocompatibility, and biological effects such as mediating cell migration and proliferation, and promoting angiogenesis and collagen deposition. Combined with the clinical electrical stimulation therapy, the conductive hydrogel primarily showed curative effects of promoting granulation tissue formation, re-epithelialization, and wound healing, providing a new treatment idea for the repair of diabetic wounds. This review summarized the research advances of electronic conductive hydrogels and ionic conductive hydrogels in recent years based on different conductive mechanisms. Meanwhile, the applications of conductive hydrogel in the diabetic wound repair were specifically introduced, and the future development of conductive hydrogel wound dressing was prospected.
作为一种新型功能性伤口敷料，导电水凝胶因其合适的电导率、良好的保湿性、优异的生物相容性以及介导细胞迁移和增殖、促进血管生成和胶原蛋白沉积等生物学效应，在伤口修复领域展现出广阔的应用前景。结合临床电刺激疗法，导电水凝胶主要表现出促进肉芽组织形成、再上皮化和伤口愈合的治疗效果，为糖尿病伤口的修复提供了新的治疗思路。本文综述了近年来基于不同导电机制的电子导电水凝胶和离子导电水凝胶的研究进展。同时，具体介绍了导电水凝胶在糖尿病伤口修复中的应用，并对导电水凝胶伤口敷料的未来发展进行了展望。
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