Department of Obstetrics and Gynecology, Cengiz Gokcek Public Hospital, Gaziantep, Turkey.
Department of Gynecology and Obstetrics, Faculty of Medicine, Yuzuncu Yıl University, Van, Turkey.
J Obstet Gynaecol. 2021 May;41(4):637-641. doi: 10.1080/01443615.2020.1789952. Epub 2020 Aug 18.
There is an increased risk of cardiovascular disease in women with premature ovarian insufficiency (POI). A relationship between cardiovascular disease and endocan levels has been shown. Endocan is a marker that is prominent in many diseases caused by endothelial dysfunction and can be measured in the blood. POI is also associated with endothelial dysfunction. The causes of POI include chromosomal and genetic defects, autoimmune processes, chemotherapy, radiation, infections and surgery, but many are unidentified (idiopathic). This study aimed to evaluate serum endocan levels in women with idiopathic POI. The blood for analysis was obtained at the early follicular phase of the menstrual cycle and endocan levels were measured using a commercially available enzyme-linked immunosorbent assay kit. There were 38 patients with idiopathic POI in the study group and 39 healthy subjects in the control group. The median ages of the women were not significantly different between the groups 34 [7] years vs. 34 [7] years, respectively ( = .862). The median endocan level was not different in the POI and control group 769 [727] vs. 1077 [403] pg/mL, respectively ( = .603). Endocan is not associated with the cardiovascular diseases risk linked with endothelial dysfunction in idiopathic POI. NCT03932877 (Clinicaltrials.gov)IMPACT STATEMENT There is an increased risk of cardiovascular disease in premature ovarian insufficiency (POI) due to the decreased level of oestrogen, which is linked with endothelial dysfunction. This study showed that endocan is not associated with the cardiovascular disease risk linked with endothelial dysfunction in idiopathic POI. A marker to be used to predict the risk of cardiovascular disease in patients with POI could facilitate in improving the quality of life of these patients. Moreover, advantageous and easy-to-measure markers are needed in larger sample studies to better understand the cardiovascular diseases risk in POI.
患有卵巢早衰（POI）的女性患心血管疾病的风险增加。已经显示出心血管疾病与内参水平之间存在关系。内参是一种在许多由内皮功能障碍引起的疾病中突出的标志物，可以在血液中测量。POI 也与内皮功能障碍有关。POI 的原因包括染色体和遗传缺陷、自身免疫过程、化疗、放疗、感染和手术，但许多原因尚未确定（特发性）。本研究旨在评估特发性 POI 女性的血清内参水平。分析用的血液是在月经周期的卵泡早期采集的，并使用市售的酶联免疫吸附测定试剂盒测量内参水平。研究组中有 38 例特发性 POI 患者，对照组中有 39 例健康受试者。两组女性的中位年龄无显著差异，分别为 34 [7] 岁和 34 [7] 岁（= 0.862）。POI 和对照组的内参水平中位数分别为 769 [727] pg/ml 和 1077 [403] pg/ml，无显著差异（= 0.603）。内参与特发性 POI 中与内皮功能障碍相关的心血管疾病风险无关。NCT03932877（Clinicaltrials.gov） 影响陈述由于雌激素水平降低，卵巢早衰（POI）患者患心血管疾病的风险增加，这与内皮功能障碍有关。本研究表明，内参与特发性 POI 中与内皮功能障碍相关的心血管疾病风险无关。一种可用于预测 POI 患者心血管疾病风险的标志物，可以改善这些患者的生活质量。此外，需要在更大的样本研究中使用有利和易于测量的标志物，以更好地了解 POI 中的心血管疾病风险。
