du Cailar J, Mathieu-Daudé J C, Deschodt J, Barlet H, Kienlen J
Ann Anesthesiol Fr. 1978;19(9):761-5.
Using the technique of the radio-immunological estimation with fentanyl-H3, a study was made in sixteen adults anaesthetised by the administration at a constant rate of alfadione and fentanyl, of plasma concentrations of fentanyl during and after anaesthesia. Anaesthesia was induced by the administration of 4.2ml of alfadione and 0.084mg of fentanyl. The maintenance dose was 0.147 ml/kg/hour of alfadione and 2.95 microgram/hg/hour of fentanyl. Five minutes after induction, the concentration of fentanyl was 2.7 microgram/l. The level fell significantly to 2.56 microgram/l at the 45th minute. From this point onwards, it increased regularly up to the 120th minute, when it reached a level of 3.7 microgram/l. When the infusion was stopped, the level first decreased rapidly, the excretion curve then becoming flattened out. At the 120th minute, a level of 1 microgram/l persisted. This study indicates that the administration of fentanyl at a constant rate is not accompanied by a constant blood concentration up to the 120th minute, the point at which the study was terminated. The residual level found after administration and in the absence of any clinical effect implies the need for a reduction in dose at the time of any complementary administration of fentanyl during the postoperative period.
采用氚标记芬太尼放射免疫测定技术，对16名以恒速输注阿法双酮和芬太尼进行麻醉的成年人在麻醉期间及麻醉后血浆芬太尼浓度进行了研究。麻醉诱导采用静脉注射4.2ml阿法双酮和0.084mg芬太尼。维持剂量为阿法双酮0.147ml/（kg·小时）和芬太尼2.95μg/（kg·小时）。诱导后5分钟，芬太尼浓度为2.7μg/L。在第45分钟时显著降至2.56μg/L。此后，浓度持续上升，至第120分钟时达到3.7μg/L。停止输注后，浓度首先迅速下降，随后排泄曲线趋于平缓。在第120分钟时，浓度维持在1μg/L。本研究表明，在第120分钟（本研究终止时间点）之前，以恒速输注芬太尼时血药浓度并不恒定。给药后在无任何临床效应情况下发现的残留浓度表明，术后再次补充芬太尼时需要减少剂量。
