du Cailar J, Mathieu-Daude J C, Deschodt J
Ann Anesthesiol Fr. 1980;21(4):445-50.
By radio-immunological estimation using fentanyl H-3, a study was undertaken in ten adults under anaesthesia of long duration obtained by infusion at a constant rate of alfadione and fentanyl of the plasma concentration of fentanyl during and after anaesthesia. Anaesthesia was induced by the administration of 4.3 ml of alfadione and 0.084 mg of fentanyl. The maintenance dose was on average 0.15 ml/kg-/h-1 +/- 0.03 of alfadione and 2.96 micrograms/kg-1/h-1 +/- 0.58 of fentanyl. The mean duration of anaesthesics was 388 minutes +/- 104. The results of this study showed that from the third hour onwards a plateau of serum concentration was established around a mean value of the order of 4.8 micrograms/l-1. The study of excretion curves demonstrated the existence of a three compartment system with respective half lives of 12.75 and 510 minutes. Maintenance of a stable plasma concentration may be explained by an increase in tissue diffusion (increase in mid and long term half life in comparison with single injections) and by increased metabolism. This study provided pharmacokinetic evidence to justify the administration of fentanyl at a constant flow rate preceded by a loading dose.
采用H-3芬太尼通过放射免疫法进行测定，对10名接受长时间麻醉的成年人开展了一项研究，麻醉通过以恒定速率输注阿法双酮和芬太尼来实现，以测定麻醉期间及之后芬太尼的血浆浓度。麻醉诱导采用4.3毫升阿法双酮和0.084毫克芬太尼。维持剂量平均为每千克每小时0.15毫升±0.03的阿法双酮和每千克每小时2.96微克±0.58的芬太尼。麻醉的平均时长为388分钟±104。该研究结果表明，从第三小时起，血清浓度在约4.8微克/升的均值附近达到平稳状态。排泄曲线研究表明存在一个三室系统，其各自的半衰期分别为12.75分钟和510分钟。血浆浓度维持稳定可通过组织扩散增加（与单次注射相比，中期和长期半衰期增加）以及代谢增加来解释。该研究提供了药代动力学证据，以证明先给予负荷剂量后以恒定流速输注芬太尼的给药方式是合理的。
