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糜烂型扁平苔藓

Lichen Planus Erosive Form

作者信息

Gall Ryan, Navarro-Fernandez Inigo N.

机构信息

NCC

Hospital Universitario Marques de Valdecilla

Abstract

Erosive lichen planus (ELP) is a variant of lichen planus which involves chronic and painful ulceration of the skin and mucosal surfaces. ELP is thought to be the result of autoimmune damage of the basal cell layer, which is mediated by activated CD8 T lymphocytes. Occasionally, ELP may present in conjunction with other clinical forms of lichen planus or may be induced by drug exposure. Clinical findings include painful, persistent ulcers, primarily of the mouth and genitals. Complications of ELP include secondary infection, development of squamous cell carcinoma, and scarring.

摘要

糜烂性扁平苔藓(ELP)是扁平苔藓的一种变体,涉及皮肤和黏膜表面的慢性疼痛性溃疡。ELP被认为是基底细胞层自身免疫损伤的结果,由活化的CD8 T淋巴细胞介导。偶尔,ELP可能与其他临床形式的扁平苔藓同时出现,或由药物暴露诱发。临床表现包括疼痛性、持续性溃疡,主要发生在口腔和生殖器。ELP的并发症包括继发感染、鳞状细胞癌的发生和瘢痕形成。

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