酿酒酵母SUP4-o基因自发突变的DNA序列分析。
DNA sequence analysis of spontaneous mutations in the SUP4-o gene of Saccharomyces cerevisiae.
作者信息
Giroux C N, Mis J R, Pierce M K, Kohalmi S E, Kunz B A
机构信息
Cellular and Genetic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
出版信息
Mol Cell Biol. 1988 Feb;8(2):978-81. doi: 10.1128/mcb.8.2.978-981.1988.
Abstract
A collection of 196 spontaneous mutations in the SUP4-o gene of the yeast Saccharomyces cerevisiae was analyzed by DNA sequencing. The classes of mutation identified included all possible types of base-pair substitution, deletions of various lengths, complex alterations involving multiple changes, and insertions of transposable elements. Our findings demonstrate that at least several different mechanisms are responsible for spontaneous mutagenesis in S. cerevisiae.
摘要
通过DNA测序分析了酿酒酵母SUP4 - o基因中的196个自发突变。鉴定出的突变类型包括所有可能的碱基对替换类型、各种长度的缺失、涉及多种变化的复杂改变以及转座元件的插入。我们的研究结果表明，至少有几种不同的机制导致了酿酒酵母中的自发诱变。
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