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本文引用的文献

1
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.洛匹那韦-利托那韦治疗成人重症 COVID-19 患者的临床试验。
N Engl J Med. 2020 May 7;382(19):1787-1799. doi: 10.1056/NEJMoa2001282. Epub 2020 Mar 18.
2
CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir.CYP3A4 介导的洛匹那韦生物活化及其被利托那韦抑制。
Drug Metab Dispos. 2012 Jan;40(1):18-24. doi: 10.1124/dmd.111.041400. Epub 2011 Sep 27.
3
Extreme bradycardia due to multiple drug-drug interactions in a patient with HIV post-exposure prophylaxis containing lopinavir-ritonavir.一名接受含洛匹那韦-利托那韦的HIV暴露后预防治疗的患者，因多种药物相互作用导致严重心动过缓。
Br J Clin Pharmacol. 2011 Apr;71(4):621-3. doi: 10.1111/j.1365-2125.2010.03849.x.
4
Bradycardia-tachycardia syndrome induced by lopinavir-ritonavir in a patient with AIDS.洛匹那韦-利托那韦诱发艾滋病患者的心动过缓-心动过速综合征。
AIDS. 2005 Sep 23;19(14):1547-8. doi: 10.1097/01.aids.0000183942.05849.1b.
5
Influence of the pro-inflammatory cytokines on P-glycoprotein expression and functionality.促炎细胞因子对P-糖蛋白表达及功能的影响。
J Pharm Pharm Sci. 2004 Nov 17;7(3):359-71.
6
Serious bradyarrhythmia that was possibly induced by lopinavir-ritonavir in 2 patients with acquired immunodeficiency syndrome.2例获得性免疫缺陷综合征患者可能由洛匹那韦-利托那韦诱发的严重缓慢性心律失常。
Clin Infect Dis. 2002 Aug 15;35(4):488-90. doi: 10.1086/341975. Epub 2002 Jul 17.

Lopinavir-Ritonavir Treatment for COVID-19 Infection in Intensive Care Unit: Risk of Bradycardia.

作者信息

Beyls Christophe, Martin Nicolas, Hermida Alexis, Abou-Arab Osama, Mahjoub Yazine

机构信息

Department of Anesthesiology and Critical Care Medicine (C.B., O.A.-A., Y.M.), Amiens University Hospital, France.

Department of Rythmology (N.M., A.H.), Amiens University Hospital, France.

出版信息

Circ Arrhythm Electrophysiol. 2020 Aug;13(8):e008798. doi: 10.1161/CIRCEP.120.008798. Epub 2020 Jul 9.

DOI:10.1161/CIRCEP.120.008798
PMID:32809882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7446985/
Abstract
摘要