Dumont A, Minjat M, Blanc J L, Vignon H
Ann Anesthesiol Fr. 1978;19(9):777-82.
This study concerns 3 cases of malignant syndrome due to neuroleptics. Our aim is to clarify the nature of this syndrome and to attempt to delimit it from malignant hyperthermia. The etiology suggests that its occurence should increase with the growing use of very active neuroleptics. It consists clinically of an extrapyramidal syndrome with hypertonicity, akinesia, tremor and with a neuro-vegetative syndrome of which the main sign is hyperthermia. On the basis of physiopathology it is attempted to explain, in the light of fresh data, the extrapyramidal signs, the hyperthermia and the rise in the OPK Etiological treatment has, however, proved disappointing.
本研究涉及3例因使用抗精神病药物引起的恶性综合征。我们的目的是阐明该综合征的性质，并试图将其与恶性高热区分开来。病因表明，随着强效抗精神病药物使用的增加，其发生率应该会上升。临床上它表现为伴有肌张力亢进、运动不能、震颤的锥体外系综合征，以及以高热为主要体征的神经植物性综合征。基于病理生理学，我们试图根据新的数据来解释锥体外系体征、高热以及磷酸肌酸激酶（CPK）升高的原因。然而，病因治疗已证明令人失望。
