Cheng Liqing, Zhou Min, Zhang Dongmei, Chen Bing
Department of Endocrinology and Metabolism, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Department of Urology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
J Int Med Res. 2020 Aug;48(8):300060520931313. doi: 10.1177/0300060520931313.
Circulating miR-146a is aberrantly expressed in patients with type 2 diabetes (T2D), probably resulting from gene polymorphisms. However, the role of polymorphism rs2910164 in T2D pathogenesis remains controversial. Thus, we designed a meta-analysis to investigate the association between rs2910164 and T2D.
PubMed and Embase were searched for eligible papers in English published through September 2, 2019. Random or fixed effect models were used to determine risk estimates according to heterogeneities.
Four studies, involving 2,069 patients and 1,950 controls, were included. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to pool the effect size. The pooled ORs and 95% CIs were 1.501 (0.887-2.541), 1.102 (0.931-1.304), 1.276 (0.900-1.811), 1.204 (0.878-1.652), 1.238 (0.880-1.740), and 1.350 (0.904-2.016) under the homozygote, heterozygote (CG vs. GG and CC vs. CG), dominant, allele, and recessive models, respectively. Heterogeneity was detected in most genetic models, with subgroup analyses performed by ethnicity, genotyping method, and disease duration. The co-dominant model was determined to be the most appropriate genetic model.
Our findings suggested that polymorphism rs2910164 is not correlated with T2D susceptibility. However, the results should be interpreted with caution because of confounding factors.
2型糖尿病（T2D）患者循环中的miR-146a表达异常，可能是由基因多态性引起的。然而，多态性rs2910164在T2D发病机制中的作用仍存在争议。因此，我们设计了一项荟萃分析来研究rs2910164与T2D之间的关联。
检索PubMed和Embase数据库，查找截至2019年9月2日发表的符合条件的英文论文。根据异质性使用随机或固定效应模型来确定风险估计值。
纳入了四项研究，共涉及2069例患者和1950例对照。采用比值比（OR）和95%置信区间（95%CI）来汇总效应量。在纯合子、杂合子（CG与GG以及CC与CG）、显性、等位基因和隐性模型下，汇总后的OR和95%CI分别为1.501（0.887 - 2.541）、1.102（0.931 - 1.304）、1.276（0.900 - 1.811）、1.204（0.878 - 1.652）、1.238（0.880 - 1.740）和1.350（0.904 - 2.016）。在大多数遗传模型中检测到异质性，并按种族、基因分型方法和病程进行了亚组分析。确定共显性模型为最合适的遗传模型。
我们的研究结果表明，多态性rs2910164与T2D易感性无关。然而，由于存在混杂因素，对结果的解释应谨慎。
