Zhang Xiuling, He Rongquan, Ren Fanghui, Tang Ruixue, Chen Gang
Department of Pathology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P.R. China.
J BUON. 2015 May-Jun;20(3):829-41.
Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of malignancies. Hence, the aim of this study was to investigate the association between this genetic variant and the susceptibility of squamous cell carcinoma (SCC).
We performed a systematic search using PubMed, EMBASE, ISI Web of Science, Cochrane Central Register of Controlled Trials, ScienceDirect, Wiley Online Library and Chinese National Knowledge Infrastructure (CNKI) databases with the last search updated on November 15, 2014. Studies were pooled and summary odds ratios (ORs) were calculated. Potential sources of heterogeneity were sought out via subgroup analysis.
A total of 12 studies (5192 cases and 9945 controls) were found to be eligible for meta-analysis. Overall, no significant associations were found between miR-146a G/C polymorphism and SCC risk when all studies were pooled into the meta-analysis. In the subgroup analysis by cancer location, statistically significantly increased risks were found for cervical SCC/CSCC (CC vs CG+GG:OR = 0.521, 95% CI=0.412-0.657,p<0.001; CC+CG vs GG:OR=1.583, 95%CI=1.215-2.062,p=0.001); and for skin SCC (GC vs CC+GG:OR=2.533, 95% CI=1.989-3.224, p<0.001). In addition, the C allele and CC genotype of rs2910164 were found to be associated with an inverse risk of nasopharyngeal carcinoma (GG vs CC:OR=0.586, 95% CI=0.405-0.847, p=0.005; CC vs CG+GG:OR=1.496, 95% CI=1.189-1.881, p=0.001). Similarly, CC genotpe of rs2910164 was found to be inversely related to susceptibility of oral SCC (CC+CG vs. GG: OR=0.726, 95% CI=0.607-0.869, p<0.001).
The miR-146a rs2910164 polymorphism is associated with increased risk for cervical and skin SCC. In contrast, rs2910164 in miR-146a is related to decreased risk for nasopharyngeal and oral SCC.
最近有证据表明，miR-146a的rs2910164变体与某些类型恶性肿瘤的发生有关。因此，本研究的目的是调查这种基因变体与鳞状细胞癌（SCC）易感性之间的关联。
我们使用PubMed、EMBASE、ISI科学网、Cochrane对照试验中心注册库、ScienceDirect、Wiley在线图书馆和中国知网（CNKI）数据库进行了系统检索，最后一次检索更新于2014年11月15日。对研究进行汇总并计算汇总比值比（OR）。通过亚组分析寻找潜在的异质性来源。
共发现12项研究（5192例病例和9945例对照）符合荟萃分析的条件。总体而言，当将所有研究纳入荟萃分析时，未发现miR-146a G/C多态性与SCC风险之间存在显著关联。在按癌症部位进行的亚组分析中，发现宫颈SCC/CSCC的风险在统计学上显著增加（CC与CG+GG相比：OR = 0.521，95%CI = 0.412 - 0.657，p < 0.001；CC+CG与GG相比：OR = 1.583，95%CI = 1.215 - 2.062，p = 0.001）；皮肤SCC也是如此（GC与CC+GG相比：OR = 2.533，95%CI = 1.989 - 3.224，p < 0.001）。此外，发现rs2910164的C等位基因和CC基因型与鼻咽癌风险呈负相关（GG与CC相比：OR = 0.586，95%CI = 0.405 - 0.847，p = 0.005；CC与CG+GG相比：OR = 1.496，95%CI = 1.189 - 1.881，p = 0.001）。同样，发现rs2910164的CC基因型与口腔SCC易感性呈负相关（CC+CG与GG相比：OR = 0.726，95%CI = 0.607 - 0.869，p < 0.001）。
miR-146a rs2910164多态性与宫颈和皮肤SCC风险增加有关。相反，miR-146a中的rs2910164与鼻咽和口腔SCC风险降低有关。
